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Standard vs High-dose Clopidogrel after PCI: GRAVITAS

Standard vs High-dose Clopidogrel after PCI: GRAVITAS.

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Standard vs High-dose Clopidogrel after PCI: GRAVITAS

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  1. Standard vs High-dose Clopidogrelafter PCI: GRAVITAS Objective: to evaluate high-dose with standard dose clopidogrel in patients with high on-treatmentplateletreactivity (≥230 PRU) after PCI Study: multicenterrandomized double-blind trialPopulation: patients with PCI with 1 or more DES for stable CAD or non-STEMI Endpoint: MACE: cardiacdeath, MI, stentthrombosisat 6 monthsSafety: severe or moderatebleeding (GUSTO definition)

  2. Standard vs High-dose Clopidogrelafter PCI: GRAVITAS

  3. Standard vs High-dose Clopidogrelafter PCI: GRAVITAS

  4. Standard vs High-dose Clopidogrelafter PCI: GRAVITAS Conclusion high-dose clopidogreldoes not reduce incidence of MACE or bleedingcompared to standard dose in patients with high on-treatmentreactivity Price JAMA 2011;305:1097-1105

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