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lethals. genes which cause death of the organism. pleiotropy. Single gene affects many traits, even seemingly unrelated ones. epistasis. One non-allelic gene pair masks another -- from Greek, “standing upon” (much like dominance). collaboration.
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lethals • genes which cause death of the organism
pleiotropy • Single gene affects many traits, even seemingly unrelated ones
epistasis • One non-allelic gene pair masks another -- from Greek, “standing upon” (much like dominance)
collaboration • Two non-allelie gene pairs produce novel phenotype (much like incomplete dominance)
Polygenic traits • 2+ non-allelic gene pairs that control a single trait
penetrance • % individuals who show phenotype expected from genotype
expressivity • degree to which a particular gene is expressed in an individual
Effects of the environment • environment affects gene expression • environmentally-produced phenotype which mimics genotype = phenocopy
Linkage • Lack of independent assortment of genes due to location on the same chromosome
Recombination • Breaks in linkage and transmission of new gene combinations on a single chromosome after prophase I crossovers
Mapping • Using crossover frequencies as relative map units – allows construction of “maps” of gene locations
Causes of Genetic Diseases*aneuploidies from nondisjunctions