Better Cancer Therapeutics through Better Biological Modeling

1. In collaboration with: Steve St. Jeor Mariana Bego Lisa Keyes The University of Nevada at Reno Better Cancer Therapeutics through Better Biological Modeling • Danna Hargett • Princeton University

2. Cancer Therapeutics Cytomegalovirus (CMV) infection has devastating effects on cancer patient survival CMV causes pneumonia 50% of the time in bone marrow transplant patients 75% mortality rate in the untreated 31% mortality rate with anti-viral treatment We need more effective CMV anti-virals

3. Immune Evasion Reactivation Dormant Infection Cancer Treatment Drugs against LUNA Cancer Therapeutics Cytomegalovirus (CMV) infection has devastating effects on cancer patient survival

4. Plan of Action Re-purify LUNA to identify LUNA binding molecules 1. 2. Add purified LUNA OrgCAST Compound Mixture Compounds which block block reactivation are potential drugs 3. Add binding molecules to infected monocytes 4. Stimulate viral Reactivation

5. Challenges • Luna is only conserved in human and chimpanzee CMV preventing small animal model testing, such as mouse • Identified drug targets may be toxic Commercialization • Identified compounds can be licensed to pharmaceutical company for clinical evaluation • Monocyte Suspension System can be adapted to other infectious agents to form core technology for further therapeutics identification