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Pharmacokinetics, Overview

Drugs need to achieve an adequate concentration in their target tissues. The two fundamental processes that determine the concentration of a drug at any moment and in any region of the body are:translocation of drug moleculeschemical transformation by drug metabolism and other processes involved

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Pharmacokinetics, Overview

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    2. Drugs need to achieve an adequate concentration in their target tissues. The two fundamental processes that determine the concentration of a drug at any moment and in any region of the body are: translocation of drug molecules chemical transformation by drug metabolism and other processes involved in drug elimination These are critically important for choosing appropriate routes of administration

    5. The Movement of Drug Molecules Across Cell Barriers, Lipid solubility: weak acids and weak bases/Clinical Significance

    6. The Movement of Drug Molecules Across Cell Barriers, Lipid solubility: weak acids and weak bases/Clinical Significance, contd.

    9. In the terminal ileum, the cobalamin-intrinsic factor complex binds to specific receptors on the mucosal brush border. In the mucosal cells, the cobalamin-intrinsic factor complex bound to receptor undergoes pinocytosis. The intrinsic factor is degraded, and cobalamin is transferred to transcobalamin-II and released into the circulation as holo transcobalamin. In the terminal ileum, the cobalamin-intrinsic factor complex binds to specific receptors on the mucosal brush border. In the mucosal cells, the cobalamin-intrinsic factor complex bound to receptor undergoes pinocytosis. The intrinsic factor is degraded, and cobalamin is transferred to transcobalamin-II and released into the circulation as holo transcobalamin.

    13. Bioavailability

    14. 2-Distribution

    15. 2-Distribution

    16. Drugs in vascular space

    17. 3-Biotransformation (Metabolism)

    18. First-pass metabolism

    19. 3-Biotransformation (Metabolism)

    20. 3-Biotransformation (Metabolism)

    21. 3-Biotransformation (Metabolism)

    22. 3-Biotransformation (Metabolism)

    23. 4- Excretion of drugs

    24. 4- Excretion of drugs

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