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GIT Module, Pathology

GIT Module, Pathology. Inflammatory Disorders of Liver. Rana Bokhary , MD, FRCPC. Inflammatory Disorders Of The Liver - Causes. Mainly infectious: Miliary T.B. Malaria Salmonelloses Candidiasis Amebiasis Viruses Others: Autoimmune Alcohol Drugs / toxins.

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GIT Module, Pathology

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  1. GIT Module, Pathology Inflammatory Disorders of Liver RanaBokhary, MD, FRCPC

  2. Inflammatory Disorders Of The Liver - Causes • Mainly infectious: • Miliary T.B. • Malaria • Salmonelloses • Candidiasis • Amebiasis • Viruses • Others: • Autoimmune • Alcohol • Drugs / toxins

  3. Viral Hepatitis - Etiology • Hepatotropic Viruses:“most common” • 5 Hepatitis viruses: HAV, HBV, HCV, HDV, HEV • HGV: non pathogenic • Other Viruses: • Herpes viruses “EBV, HSV & CMV” • Yellow fever • Rubella • Adenovirus • Enterovirus

  4. The Hepatitis Viruses (Table 16-4)

  5. Potential Outcomes of HBV Infection

  6. Potential Outcomes Of HCV Infection

  7. Clinical Syndromes & Outcomes of Hepatitis • Asymptomatic acute infection: Serologic evidence only • Acute Hepatitis: Icteric or anicteric • Chronic Hepatitis: With or without progression to cirrhosis • Chronic carrier state: Asymptomatic without apparent disease • Fulminant Hepatitis: Submassive to massive necrosis  acute liver failure • HAV, HCV & HEV do not generate a carrier state • HAV & HEV do not progress to chronic hepatitis

  8. Acute Viral Hepatitis

  9. Acute Viral Hepatitis

  10. Ballooning Degeneration

  11. Apoptotic Cell

  12. Portal Tract Infiltrate with Interface Hepatitis

  13. HBsAg Immunostain Ground Glass Cell HBV

  14. HCV – Lymphoid Follicles

  15. HCV - Steatosis

  16. Chronic HCV Hepatitis

  17. Cirrhosis Secondary to Viral Hepatitis

  18. Cirrhosis

  19. Main Morphologic Features of Acute & Chronic Viral Hepatitis Table 16-5

  20. Main Morphologic Features of Acute & Chronic Viral Hepatitis Table 16-5

  21. Liver shrinks in size  wrinkled capsule

  22. Area of collapse Massive Hepatic Necrosis

  23. Collapsed parenchyma in Hepatitis

  24. Liver Abscesses • Common in developing countries • Rare in developed countries • Causes of each • Routes of infection • Clinical features • Management

  25. Autoimmune Hepatitis • Syndrome of chronic hepatitis in persons with a heterogenous set of immunologic abnormalities

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