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GIT Module, Pathology. Inflammatory Disorders of Liver. Rana Bokhary , MD, FRCPC. Inflammatory Disorders Of The Liver - Causes. Mainly infectious: Miliary T.B. Malaria Salmonelloses Candidiasis Amebiasis Viruses Others: Autoimmune Alcohol Drugs / toxins.
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GIT Module, Pathology Inflammatory Disorders of Liver RanaBokhary, MD, FRCPC
Inflammatory Disorders Of The Liver - Causes • Mainly infectious: • Miliary T.B. • Malaria • Salmonelloses • Candidiasis • Amebiasis • Viruses • Others: • Autoimmune • Alcohol • Drugs / toxins
Viral Hepatitis - Etiology • Hepatotropic Viruses:“most common” • 5 Hepatitis viruses: HAV, HBV, HCV, HDV, HEV • HGV: non pathogenic • Other Viruses: • Herpes viruses “EBV, HSV & CMV” • Yellow fever • Rubella • Adenovirus • Enterovirus
Clinical Syndromes & Outcomes of Hepatitis • Asymptomatic acute infection: Serologic evidence only • Acute Hepatitis: Icteric or anicteric • Chronic Hepatitis: With or without progression to cirrhosis • Chronic carrier state: Asymptomatic without apparent disease • Fulminant Hepatitis: Submassive to massive necrosis acute liver failure • HAV, HCV & HEV do not generate a carrier state • HAV & HEV do not progress to chronic hepatitis
HBsAg Immunostain Ground Glass Cell HBV
Main Morphologic Features of Acute & Chronic Viral Hepatitis Table 16-5
Main Morphologic Features of Acute & Chronic Viral Hepatitis Table 16-5
Area of collapse Massive Hepatic Necrosis
Liver Abscesses • Common in developing countries • Rare in developed countries • Causes of each • Routes of infection • Clinical features • Management
Autoimmune Hepatitis • Syndrome of chronic hepatitis in persons with a heterogenous set of immunologic abnormalities