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10,000 foot view of what I am working on. Wendy W. Chapman, PhD. Biomedical Language Understanding. University of Pittsburgh. Dept of Biomedical Informatics. Background. U of Utah. Wisconsin. U of Utah. U of Pittsburgh. 1992. 1994. 2000. 2003. BA Linguistics. Post-doc BMI.
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10,000 foot view of what I am working on Wendy W. Chapman, PhD Biomedical Language Understanding University of Pittsburgh Dept of Biomedical Informatics
Background U of Utah Wisconsin U of Utah U of Pittsburgh 1992 1994 2000 2003 BA Linguistics Post-doc BMI Faculty DBMI PhD Medical Informatics Chinese Literature
Biomedical Language Understanding Henk Harkema, Danielle Mowery, Mike Conway, Lee Christensen, Qi Li, Wendy Chapman www.dbmi.pitt.edu/blulab
BLU Lab NLP Sampler Topaz Onyx Ontology Enrichment Results Review/ Error Analysis Anaphoric Reference Temporality Schema NLP Repository Ontology For Syndromic Surveillance
BLU Lab NLP Sampler Topaz Onyx Ontology Enrichment Results Review/ Error Analysis Anaphoric Reference Temporality Schema NLP Repository Ontology For Syndromic Surveillance
Topaz Harkema, B Chapman, Hwa • Named entity recognition • Maps UMLS concepts to higher-level concepts • Contextual property assignment (ConText) • Existence (affirmed, negated) • Experiencer (patient, other) • Historicity (current, historical) • Realis (actual, non-specific/hypothetical) • Certainty (uncertain, certain) • Reason for exam (yes, no) • Quality of exam (diagnostic, limited)
ConText: Determine Values for Contextual Properties Clinical condition: Cough Negation: Negated scope Patient deniescoughbut complains of headache. No change in the patient’s chest pain. trigger term termination term pseudo-trigger term
ConText: Historical scope Past history of pneumoniapresenting today with cough and fever. termination term trigger term Clinical condition: Pneumonia Temporality: Historical
BLU Lab NLP Sampler Topaz Onyx Ontology Enrichment Results Review/ Error Analysis Anaphoric Reference Temporality Schema NLP Repository Ontology For Syndromic Surveillance
Haug, Schleyer Onyx Eight mesial might have a slight translucency Semantic Models Syntactic Analyzer Onyx Semantic Analyzer Context-free Grammar Training Corpus At (translucency, numberEight) & surfaceOf (numberEight, mesial) & stateOf (translucency, possible)
Knowledge-rich Frame-based Mapping Semantic Network Probabilistic Frames - Frame slots map to semantic network - Relationships between slots are probabilistic
Annotation Interface Semantic Model with active learning and help from Onyx Templates
Speech NLP Chart Dental Exams Number one Is missing. Two is fine. Caries on Tooth 3. Onyx Titus Schleyer, Lee Christensen, Peter Haug, Jeannie Irwin, Henk Harkema
BLU Lab NLP Sampler Topaz Onyx Ontology Enrichment Results Review/ Error Analysis Anaphoric Reference Temporality Schema NLP Repository Ontology For Syndromic Surveillance
Ontology Development-Information Extraction (ODIE) Rebecca Crowley, Mayo Clinic, Stanford NCBO Information Extraction Use ontology to improve IE from text Ontology Text Ontology Enrichment Use IE to find new concepts and relationships to add Surgical Pathology Chest Radiography
BLU Lab NLP Sampler Topaz Onyx Ontology Enrichment Results Review/ Error Analysis Anaphoric Reference Temporality Schema NLP Repository Ontology For Syndromic Surveillance
BLU Lab NLP Sampler Topaz Onyx Ontology Enrichment Results Review/ Error Analysis Anaphoric Reference Temporality Schema NLP Repository Ontology For Syndromic Surveillance
Schema for Clinical Condition Properties Wiebe, Jordan, Mowery, Harkema Properties of Condition Concept Existence Yes, No Experiencer Patient, Other Change Unmarked, Unchanging, Changing, Increasing, Decreasing, Improving, Worsening, Recurrence Intermittent Unmarked, Yes, No Certainty Unmarked, High, Moderate, Low Mental State Yes, No Generalized/ Conditional Yes, No Current Visit Relation Before, Meets_Overlaps, After
Schema for Temporal Relations Time Words Points, Durations Ordering Words Precedes, During, Follows Aspectual Words Initiation, Continuation, Culmination
BLU Lab NLP Sampler Topaz Onyx Ontology Enrichment Results Review/ Error Analysis Anaphoric Reference Temporality Schema NLP Repository Ontology For Syndromic Surveillance
BLU Lab NLP Sampler Topaz Onyx Ontology Enrichment Results Review/ Error Analysis Anaphoric Reference Temporality Schema NLP Repository Ontology For Syndromic Surveillance
Application Ontology for Syndromic Surveillance Consensus of developers/users across country Conway, Buckeridge
BLU Lab NLP Sampler Topaz Onyx Ontology Enrichment Results Review/ Error Analysis Anaphoric Reference Temporality Schema NLP Repository Ontology For Syndromic Surveillance
Anaphoric Reference in Clinical ReportsCrowey, Savova, Zeng • Adapted MUC schema for clinical reports • Three experts annotated 180 reports Five types—Mayo, UPMC • identity • part/whole • set/subset • Characterize anaphoric reference in reports • Train/test resolution algorithms