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Path Analysis. Research questions. Is SNP rs10879357 associated with CWP? How are depression and/or sleep problems involved in this relationship?. Step 1 – SNP associated with CWP?. 1.8. SNP. CWP. Step 2 – is this association independent of depression?. 1.6. SNP. CWP. 1.4. Depression.
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Research questions • Is SNP rs10879357 associated with CWP? • How are depression and/or sleep problems involved in this relationship?
1.8 SNP CWP
1.6 SNP CWP 1.4 Depression
1.6 SNP CWP 1.02 1.4 Depression
1.7 SNP CWP 1.3 Sleep problems
1.7 SNP CWP 1.3 1.01 Sleep problems
Path model SNP Depression CWP Sleep problems
Path model – in STATA • pathreg command • models each potential pathway
Path model 0.08 0.04 0.19 SNP Depression CWP 0.05 r2=0.53 0.56 0.48 Sleep problems 0.999 0.827 0.783