Bio 98 - Lecture 10 Enzymes III: Competitive Inhibition Enzyme Regulation

Oct 01, 2012

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Bio 98 - Lecture 10 Enzymes III: Competitive Inhibition Enzyme Regulation

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REGULATION OF ENZYME ACTIVITY

REGULATION OF ENZYME ACTIVITY . Medical Biochemistry, Lecture 25. Lecture 25, Outline. General properties of enzyme regulation Regulation of enzyme concentrations Allosteric enzymes and feedback inhibition Other effectors of catalytic activity. Metabolic Homeostasis.

2.74k views • 32 slides

Enzyme Activity

Enzyme Activity. The properties of enzymes related to their tertiary structure.The effects of change in temperature,pH,substrate concentration,and competitive and non-competitive inhibition on the rate of enzyme action.

1.57k views • 10 slides

Chapter 21 Enzymes and Vitamins

Chapter 21 Enzymes and Vitamins. 21.5 Enzyme Inhibition 21.6 Regulation of Enzyme Activity 21.7 Enzyme Cofactors. Enzyme Inhibition. Inhibitors : Are molecules that cause a loss of catalytic activity. Prevent substrates from fitting into the active sites. E + S ES E + P

720 views • 16 slides

Lecture 16

Lecture 16. Inhibition Quiz on Friday, Oct. 14 (MM derivation (assume no E+P -> ES) and 6 enzyme classes-what types of reactions do they catalyze?). X. Y. X. Y. X. Y. Enzymes. Oxidoreductases: A - + B  A + B - Transferases: A-B + C  A + B-C Hydrolase: A-B + H 2 O  A-H + B-OH

1.2k views • 39 slides

ENZYMES

ENZYMES. ENZYME STRUCTURE. ENZYME. Enzymes are proteins that speed up chemical reactions. (catalyst) Enzymes do not change when they perform their function, and can be used over & over again.

545 views • 15 slides

ENZYMES

ENZYMES. Outline. Review – What is an enzyme? Models of enzyme activity Lock and key Induced fit model Factors affecting enzyme activity Temperature pH Regulation of enzyme activity Inhibition Allosterically Feedback inhibition. What is an enzyme?. “Biological catalysts”:

627 views • 36 slides

Content of Enzyme Technology

Content of Enzyme Technology. Why enzymes? Enzyme nomenclature Enzyme units The mechanism of enzyme catalysis Simple kinetics of enzyme action Effect of pH and ionic strength Effect of temperature and pressure Reversible reactions Enzyme inhibition Determination of Vmax and Km

1.85k views • 143 slides

Inhibited Enzyme Kinetics

Inhibited Enzyme Kinetics. Inhibitors may bind to enzyme and reduce their activity. Enzyme inhibition may be reversible or irreversible. For reversible enzyme inhibition, there are - - -. Inhibited Enzyme Kinetics. Competitive inhibitors (I) - substrate analogs

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Lecture 15

Lecture 15. Chemical Reaction Engineering (CRE) is the field that studies the rates and mechanisms of chemical reactions and the design of the reactors in which they take place. Lecture 15 – Thursday 2/24/2011. Enzymes Michealis-Menten Kinetics Lineweaver -Burk Plot Enzyme Inhibition

437 views • 29 slides

Gene Regulation

Gene Regulation. 2/23/09. Fig. 18-2. Precursor. Feedback inhibition. trpE gene. Enzyme 1. trpD gene. Regulation of gene expression. trpC gene. Enzyme 2. trpB gene. Enzyme 3. trpA gene. Tryptophan. (a) Regulation of enzyme activity. (b) Regulation of enzyme production.

614 views • 25 slides

Gene Regulation Ch. 18

Gene Regulation Ch. 18. Precursor. Feedback inhibition. Figure 18.2. trpE gene. Enzyme 1. trpD gene. Regulation of gene expression. Enzyme 2. trpC gene. . trpB gene. . Enzyme 3. trpA gene. Tryptophan. (b). (a). Regulation of enzyme activity.

667 views • 40 slides

بسم الله الرحمن الرحيم

بسم الله الرحمن الرحيم . Enzymes. Objectives. What are enzymes ? Properties of enzymes Classification Factors Affecting Enzyme Action Enzyme Kinetics Inhibition of Enzyme Activity Regulation of Enzyme Activity. Criteria معايير of Enzymes. They are : organic catalysts ,

965 views • 62 slides

Lecture 15

Lecture 15. Chemical Reaction Engineering (CRE) is the field that studies the rates and mechanisms of chemical reactions and the design of the reactors in which they take place. Today’s lecture. Enzymes Michealis-Menten Kinetics Lineweaver -Burk Plot Enzyme Inhibition Competitive

440 views • 31 slides

Competitive Inhibition

Competitive Inhibition. Competitive Inhibition. Uncompetitive Inhibition. Mixed Inhibition. Inhibiting a Carboxypeptidase. Carboxypeptidases bind peptides and cleave peptide bonds Design inhibitor that matches the active site. Inhibiting ACE. Complementary inhibitors Thiols are effective

690 views • 22 slides

Enzyme Inhibition (26.4)

Enzyme Inhibition (26.4). Inhibition is a term used to describe the inability of a product being formed due to the presence of another substance (the inhibitor) Enzyme inhibition can be competitive or noncompetitive

391 views • 6 slides

Enzymes

Enzymes. Objectives: (a) explain that enzymes are globular proteins that catalyse metabolic reactions; (b) explain the mode of action of enzymes in terms of an active site, enzyme/substrate complex, lowering of activation energy and enzyme specificity; . Enzymes.

556 views • 21 slides

Enzyme Regulation

Enzyme Regulation. Andy Howard Introductory Biochemistry 12 November 2008. Enzymes are under several levels of control. Some controls operate at the level of enzyme availability Other controls are exerted by thermodynamics, inhibition, or allostery. Globins as Examples Oxygen binding

1.25k views • 46 slides

Chapter 15 Enzyme Regulation

Chapter 15 Enzyme Regulation. Outline. What factors influence enzymatic activity? What are the general features of allosteric regulation? Can allosteric regulation be explained by conformational changes in proteins? What kinds of covalent modification regulate the activity of enzymes?

1.24k views • 62 slides

Enzymes, Regulation, And Inhibition By Nic Oliver And Jamie Gephart

Enzymes, Regulation, And Inhibition By Nic Oliver And Jamie Gephart. Enzymes A protein that acts as a catalyst for chemical reactions to occur within an organism. Molecular model of lipase. Enzyme Roles and Characteristics

1.71k views • 31 slides

Chap. 6A Enzymes

Chap. 6A Enzymes. Introduction to Enzymes How Enzymes Work Enzyme Kinetics as an Approach to Understanding Mechanism Examples of Enzymatic Reactions Regulatory Enzymes. Fig. 6-22. The chymotrypsin enzyme-substrate complex. Intro. to Enzymes.

992 views • 46 slides

Enzyme regulation by Allosteric control (include feedback inhibition)

Enzyme Regulation - Regulatory Strategies. Enzyme regulation by Allosteric control (include feedback inhibition) Stimulation and inhibition by control proteins Reversible covalent modification Proteolytic activation. Allosteric Control Example: Feedback Inhibition. Feedback inhibition

672 views • 16 slides

ENZYME INHIBITION

ENZYME INHIBITION. TEACHER: SIDDHARTH V. PATIL SCHOOL : PODAR INTERNATIONAL SCHOOL SUBJECT: BIOLOGY (HL). induced fit model. Competitive inhibitors This is the most straightforward and obvious form of enzyme inhibition - and the name tells you exactly what happens.

648 views • 21 slides

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