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90 m M TMS

Vehicle control (DMSO). 3 m M TMS. 30 m M TMS. 10 m M TMS. 90 m M TMS. Supplemental Fig. 2a. 100. 75. 50. 37. 25. 20. 15. Caspase 2. 75. 250. 150. 50. 100. 75. 37. 50. 25. 37. 20. 25. 15. 20. Caspase 8. 15. b -actin. 10 m M TMS. 30 m M TMS. 90 m M TMS.

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90 m M TMS

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  1. Vehicle control (DMSO) 3 mM TMS 30 mM TMS 10 mM TMS 90 mM TMS Supplemental Fig. 2a.

  2. 100 75 50 37 25 20 15 Caspase 2 75 250 150 50 100 75 37 50 25 37 20 25 15 20 Caspase 8 15 b-actin 10 mM TMS 30 mM TMS 90 mM TMS 3 mM TMS 10 mM TMS 30 mM TMS 90 mM TMS 3 mM TMS DMSO DMSO 100 75 50 Pro-caspase 2 Pro-caspase 7 37 25 20 Cleaved caspase 7 15 If Caspase 7 is active we expect to see a band at 20 KDa Cleaved caspase 2 If Caspase 2 is active we expect to see a band at 12, 14 KDa Caspase 7 10 mM TMS 30 mM TMS 90 mM TMS 3 mM TMS 10 mM TMS 30 mM TMS 90 mM TMS 3 mM TMS DMSO DMSO Procaspase 8 p41 Caspase 8 p18 If Caspase 8 is active we expect to see a band at 18 KDa Supplemental Fig. 2b.

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