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Ouderen en kanker in Limburg

Ouderen en kanker in Limburg. Frank Buntinx, Laura Deckx, Marjan Van den Akker Gerionne 9.11.2011. Analysis of the RNH and Intego databases: prevalent and subsequent co-morbidity in cancer and non-cancer patients. KLIMOP: a cohort study on cancer in older cancer patients. Co-morbidity.

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Ouderen en kanker in Limburg

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  1. Ouderen en kanker in Limburg Frank Buntinx, Laura Deckx, Marjan Van den Akker Gerionne 9.11.2011

  2. Analysis of the RNH and Intego databases: prevalent and subsequent co-morbidity in cancer and non-cancer patients. • KLIMOP: a cohort study on cancer in older cancer patients.

  3. Co-morbidity

  4. Co-morbidity in cancer and non-cancerpatients • RNH: GP-based database. ‘serious’ morbidity of 131.920 patients , 69 GPs in Limburg. • Included: all cancer cases diagnosedbetween 1998-2007, all skin cancersexcluded. • Prevalentco-morbidity: cross-sectional design. • Subsequentmorbidity: (retrospective) cohort design, FU=6 months to 5 yearsafter diagnosis. • 3.544 cancerpatients, 11.060 non-cancerpatients, matched on age, sex and practice. • Ifapplicable, the last threemonthsbeforedeathwereexcluded.

  5. Pre-existing (Men)

  6. Pre-existing (Women)

  7. Pre-existing (men) - categories

  8. Subsequent (men) - categories

  9. Subsequent (men) - CVD

  10. Subsequent (men)10 most common diseases

  11. Subsequent (women) - CVD

  12. KLIMOP What is the influence of a cancer diagnosis, ageing and the interaction between them on general wellbeing of older patients?

  13. Influence of cancer diagnosis, ageing & their interaction on general wellbeing Wellbeing: • Co-morbidity • ADL, IADL, cognition, depression, Quality of life • Loneliness & socialnetwork Ageing: • Age (years)? • Frailty? • Telomerelength? • Immunologicalageing?

  14. Design Ageing Cancer

  15. Interview Info from medical files 2 samples of cheek mucosa (questionnaire carers)

  16. KLIMOP: inclusion Aim: 2 x 375 per group

  17. Baseline

  18. Baseline IADL: women (score between 0 – 8) IADL: men (score between 0 – 6, extra question on reparations added) GDS-15: 0 - 4 = normal, ≥ 5 depressive feelings MMSE: normal (30 – 25), impaired(≤ 24)

  19. Loneliness *: loneliness scale of De Jong-Gierveld most lonely patients were slightly lonely (only 8 scored > 8/11) Significant positive relation with QoL in both groups of cancer patients Significant relation with functional status (limited in > 2 domains): significant in older cancer patients only: OR= 4,3 (1,3-13,7) Relation with living situation (with others – alone) not significant

  20. Baseline Depression ~ Fatigue* * Fatigue is measured with the EORTC QLQ-C30 subscale. A higher score means more (max = 100)

  21. Global Quality of life:Baseline ~ 6 months Depression: no significant differences Cognition: no significant differences n=165

  22. Fatigue:Baseline ~ 6 months P=0.01 (worsening – no worsening) n = 162

  23. Deckx L, Van Abbema D, Nelissen K, Daniels L, Stinissen P, Bulens P, Linsen L, Rummens JL, Van den Berkmortel F, Robaeys G, De Jonge E, Houben B, Pat K, Walgraeve D, Spaas L, Verheezen J, Verniest T, Goegebuer A, Wildiers H, Tjan-Heijnen V, Buntinx F, Van den Akker M, Research group on older cancer patients. Study protocol of KLIMOP: a cohort study on the wellbeing of older cancer patients in Belgium and the Netherlands. BMC Publ Health 2011; 11: 825 contact: laura.deckx@med.kuleuven.be - doris.van.abbema@mumc.nl

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