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RHABDOVIRIDAE

RHABDOVIRIDAE. PETER H. RUSSELL, BVSc, PhD, FRCPath, MRCVS Department of Pathology and Infectious Diseases, The Royal Veterinary College, Royal College Street, London NW1 OTU. E-mail Web site. LEARNING OBJECTIVES Students should be able to:.

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RHABDOVIRIDAE

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  1. RHABDOVIRIDAE PETER H. RUSSELL, BVSc, PhD, FRCPath, MRCVS Department of Pathology and Infectious Diseases, The Royal Veterinary College, Royal College Street, London NW1 OTU. E-mailWeb site

  2. LEARNING OBJECTIVESStudents should be able to: • Describe rabies pathogenesis in mammals, including bats • Relate rabies epidemiology in different countries to the control measures used. • Name the four requirements in the rabies control strategy recently introduced as an alternative to quarantine in the UK.

  3. FAMILY CHARACTERISTICS: (Rhabdo = rod )

  4. RABIES DISEASE & PATHOGENESIS Notifiable; zoonotic; rare in UK but several cases have been veterinarians!

  5. RABIES DISEASE & PATHOGENESIS Non-fatal infections are rare but skunks and foxes may recover; dogs can have mild symptoms, recover and remain as excretors. Recovered animals have antibodies. These infections are important in spreading the virus in the environment.

  6. RABIES ANTIGENICITY:only one type required in vaccine

  7. RABIES HOST RANGE: All mammals are susceptible including bats

  8. RABIES CONTROL: The strategy depends on whether rabies is endemic or whether the country is free of virus. Virus-free countries:

  9. RABIES CONTROL: Virus endemic countries:

  10. RABIES CONTROL: In humans:

  11. Summary • Rabies targets the nervous system and brain causing a fatal infection; transmitted by biting as virus in saliva; zoonotic. • Rabies-free countries aim to keep rabies out by quarantine; countries with endemic rabies in wildlife control rabies by reducing wildlife numbers +/- vaccination of wildlife. • In the UK, the Pet Travel Scheme has been introduced to replace quarantine but for movements between specified countries only.

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