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targetncer

http://target.cancer.gov. Areas for TARGET Initiative Research Focus. Underlying premise: Genes that are altered in expression, copy number, or LOH and mutation will highlight cellular pathways for therapeutic exploitation Approach:

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targetncer

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  1. http://target.cancer.gov

  2. Areas for TARGET Initiative Research Focus Underlying premise: Genes that are altered in expression, copy number, or LOH and mutation will highlight cellular pathways for therapeutic exploitation Approach: • High-throughput array-based technologies to comprehensively characterize genomic and transcriptomic profiles • Gene resequencing to identify genes that are consistently altered in specific childhood cancers • Functional validation to validate putative therapeutic targets

  3. Cancer TARGET Initiative Strategy for ALL and Neuroblastoma Projects Disease Expertise – COG Disease Committee Genomic Characterization Expertise Gene Sequencing Expertise Transcriptomic Characterization Expertise Clinical Specimens

  4. Speakers for the ALL and Neuroblastoma TARGET Teams • Stephen P. Hunger, MD (ALL TARGET) • Professor and Ergen Family Chair in Pediatric Cancer • Director, Center for Cancer and Blood Disorders • Chief, Pediatric Hematology/Oncology/BMT • University of Colorado Denver and The Children’s Hospital • Chair, COG ALL Committee • John M. Maris, MD (Neuroblastoma TARGET) • Giulio D'Angio Associate Professor of Pediatrics • Chief, Division of Oncology • Director, Center for Childhood Cancer Research • Children's Hospital of Philadelphia • University of Pennsylvania School of Medicine • Chair, COG Neuroblastoma Committee

  5. Identifying More Effective Treatments for Children with Cancer TARGET Discovery Programs Pediatric Preclinical Testing Phase 1 Clinical Trial (COG, NANT, PBTC, CCR) COG Definitive Clinical Trial

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