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Prions : The Newest Disease Agents

Prions : The Newest Disease Agents. Do Now: Complete the chart on your notes as completely as possible. Transmissible Spongiform Encephalopathy (TSE). TSE is a group of diseases caused by prions . A prion is a disease-causing protein. Common types of TSE: “Mad Cow Disease” (BSE)

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Prions : The Newest Disease Agents

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  1. Prions: The Newest Disease Agents Do Now: Complete the chart on your notes as completely as possible

  2. Transmissible Spongiform Encephalopathy (TSE) • TSE is a group of diseases caused by prions. • A prion is a disease-causing protein. • Common types of TSE: • “Mad Cow Disease” (BSE) • Scrapie • Kuru • Creutzfeldt-Jakob disease

  3. How Prions Cause disease • This is a normal protein in your brain. • It has important functions your brain needs

  4. Same Protein, 2 Shapes Normal Protein Disease Protein (prion)

  5. When Good Proteins Go Bad • The prion changes the shape of the normal protein, making it defective and infectious.

  6. So What About the Cow? Brain tissue of infected cow: spongiform

  7. Transmission: Cannibalism • Prions that cause disease are eaten, and then begin transforming proteins in the new victim. • Mad cow disease can be transmitted to humans (200+ known cases) • So how did cows get prions from other cows?

  8. Rendering Factories • Industrial animal production feeds animals the remains of dead animals.

  9. “Downer” cattle: now outlawed as feed

  10. Mmmm… Uncle Larry!

  11. The Meatrix • Industrial food production (CAFOs) have had major effects on human health, as demonstrated in this unit: • H1N1 influenza • BSE • Other implications we have not considered that affect humans: • Pollution (12,000,000 tons of animal waste/day) • Antibiotic resistance (70% of all antibiotics fed to animals) • Animal welfare

  12. But Before We Do

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