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IRISPCPBPIKDAMP PBPK DMACPBBHTCPDDTPCBPELPPHBAP

IRISPCPBPIKDAMP PBPK DMACPBBHTCPDDTPCBPELPPHBAP. Outline. What is PBPK? Uses of PBPK Model structure Examples. PBPK. Physiologically Based PharmacoKinetic Predicting absorption, distribution, metabolism and elimination (ADME) Exposure → effects Linear Probit. When to use.

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IRISPCPBPIKDAMP PBPK DMACPBBHTCPDDTPCBPELPPHBAP

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  1. IRISPCPBPIKDAMPPBPKDMACPBBHTCPDDTPCBPELPPHBAP

  2. Outline • What is PBPK? • Uses of PBPK • Model structure • Examples

  3. PBPK • Physiologically Based PharmacoKinetic • Predicting absorption, distribution, metabolism and elimination (ADME) • Exposure → effects • Linear • Probit

  4. When to use • ADME changes with time or age, species, exposure level or between individuals

  5. Uses of PBPK • Pharmaceutical research (drugs) • Health risk assessment (cosmetics, toxins)

  6. Model structure • Mathematical compartment model • Mechanistic • A priori – anatomy, physiologial structure

  7. Model structure • Compartments for organs and tissues • Transfers for blood or lymph flows • Parameters for blood flow rate, ventilation rate, organ volume

  8. Model structure • Inputs: inhalation, ingestion, dermal exposure, injection • Outputs: excretion, exhalation, degradation, metabolism

  9. Model structure Cven.blood ·Fblood VeneousBlood Cmuscle ·Fmuscle Muscle Cart.blood · Fmuscle ArterialBlood

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