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Gabriele Riccardi Chair of Endocrinology and Metabolic Diseases,

Diabete e danno vascolare: il nesso fisiopatologico comune tra micro e macroangiopatia. Gabriele Riccardi Chair of Endocrinology and Metabolic Diseases, Federico II University, Naples, Italy. Riccardi G et al, ATVB 1988. Retinopathy predicts cardiovascular events in type 2 diabetes.

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Gabriele Riccardi Chair of Endocrinology and Metabolic Diseases,

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  1. Diabete e danno vascolare: il nesso fisiopatologico comune tra micro e macroangiopatia Gabriele Riccardi Chair of Endocrinology and Metabolic Diseases, Federico II University, Naples, Italy

  2. Riccardi G et al, ATVB 1988

  3. Retinopathy predicts cardiovascular events in type 2 diabetes Rosenson RS et al, Atherosclerosis 2011

  4. Multivariate-adjusted hazard ratio of CV events, renal events, all-cause mortality and composite events in Type 2 Diabetes in relation to preexisting microangiopathy P.C.Y. Tong, Diabetic Medicine 2007

  5. Fattori di rischio per lo sviluppo delle complicanze croniche Fattori genetici Compenso glicemico insoddisfacente Durata del diabete Dislipidemia Ipertensione arteriosa Fumo di sigaretta Sovrappeso Sedentarietà Infiammazione subclinica

  6. Prognostic value of the Metabolic Syndrome in diabetic patients THE METASCREEN WRITING COMMITTEE* Diabetes Care, 2006

  7. Tight BP control (BP <150/85 mm Hg) Tight glucose control(FPG <6 mmol/L) UKPDS: Effect of Tight BP vs Tight Glucose Control on CV Events Microvascular Outcomes Any Diabetes End Point Stroke Death 0 -10 -20 % Reduction p< 0.05 -30 p< 0.05 p< 0.05 -40 p< 0.05 -50 UKPDS Group, BMJ 1998

  8. Fenofibrate reduces progression to microalbuminuria over 3 years in a placebo-controlled study in type 2 diabetes: results from the Diabetes Atherosclerosis Intervention Study (DIAS). Ansquer JC et al, Am J Kidney Dis 2005

  9. Proposed mechanisms linking insulin-resistance and/or hyperinsulinemia with atherosclerosis Insulin-resistance HDL-Col Small LDL Post prandial Triglyceride Platelet aggregation NO Glycemia Lifestyle - Genetics arterial wall Muscle cell proliferation PAI-1 SNS O+ Hyperinsulinemia

  10. General features of the hyperglycaemia induced tissue damage WV Brown, Am J Cardiol 2008

  11. Adesione Leucociti Citochine Chemochine PCK AGEs ROS Ossido Nitrico Vasodilatazione Proliferazione Migrazione ALTERAZIONI DELLA FUNZIONE ENDOTELIALE INDOTTE DALL’IPERGLICEMIA

  12. Incidence of complications in patients with type 2 diabetes by HbA1c- UKPDS observational study HbA1c % BMJ 2000

  13. Adjusted hazard ratios (HR) for all-cause mortality by HbA1c deciles in people given oral hypoglycemic treatment Currie CJ et al, Lancet 2010

  14. N Engl J Med 2008;358:2545-59

  15. THE ACCORD STUDY

  16. an aortic complicated atheromatous lesion with rupture of its fibreous cap M= media, T= thrombus, LC=lipid core, FC= fibrous cap

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