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Overlap of Atherosclerotic Disease

Overlap of Atherosclerotic Disease. Coronary Disease. Cerebrovascular Disease. Peripheral Arterial Disease. Patients with one manifestation often have coexistent disease in other vascular beds. 1. The 3 Steps of Platelet Aggregation. Adhesion. Aggregation. von Willebrand

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Overlap of Atherosclerotic Disease

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  1. Overlap of Atherosclerotic Disease CoronaryDisease CerebrovascularDisease Peripheral Arterial Disease Patients with one manifestation often have coexistent disease in other vascular beds 1

  2. The 3 Steps of Platelet Aggregation Adhesion Aggregation von Willebrand Factor/GPlb bind Platelets Fibrinogen Collagen GPla/lla bind Lipid core Activated GPllb/llla Platelet Activation Thrombin ADP 5 HT TXA2 Adaptec from Schafer. Am J Med 1996;101:199-209.

  3. Atherosclerotic Plaque Stable Unstable Lumen Endothelium Thrombus Platelets Lipid Rich Core ThickFibrous Cap ThinFibrous Cap Falk E et al. Circulation. 1995;92:657-671. 3

  4. Pressures Needed To Calculate The Ankle-Brachial Index (ABI) Right Arm Pressure: Left Arm Pressure: ABI Interpretation Above 0.90 — Normal 0.71-0.90 — Mild Obstruction 0.41-0.70 — Moderate Obstruction 0.00-0.40 — Severe Obstruction Pressure: Pressure: PT PT DP DP ABI = Ankle pressure/Brachial pressure

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