The Most Effective Weight Loss Supplement - Rimonabant Powder (AASraw)

1. Email: aas11@aasraw.com Whatsapp:+8618928439036 The most effective weight loss supplement-- Rimonabant powder 1. History of Rimonabant.................................................................................................................... 1 2. Rimonabant.....................................................................................................................................2 3. Brand Name of Rimonabant Variations.......................................................................................... 3 4. Rimonabant powder........................................................................................................................3 5. Mechanism of action-- Rimonabant powder..................................................................................3 6. How does Rimonabant powder work?........................................................................................... 3 7. What is Rimonabant powder used for?..........................................................................................4 8. Rimonabant for overweight or obesity...........................................................................................4 9. Rimonabant powder dosage...........................................................................................................5 10. Advantages of Rimonabant & the Rimonabant benefits..........................................................6 11. The warning on Rimonabant.........................................................................................................8 12. Side effects of Rimonabant powder..............................................................................................8 13. Rimonabant Review.......................................................................................................................9 (1) Safety– “Serious Health Concerns”....................................................................................... 9 (2) Availability– “Not Approved in Most Countries”.................................................................10 (3) The Science – “Strong Clinical Support?”............................................................................10 14. Rimonabant tablet Recipe...........................................................................................................11 15. Does Rimonabant powder also aid smoking cessation?............................................................ 12 16. What were the results of Rimonabant powder clinical trial studies?........................................12 17. Rimonabant for prevention of cardiovascular events................................................................13 (1) Background..........................................................................................................................13 (2) Methods...............................................................................................................................13 (3) Findings................................................................................................................................14 (4) Interpretation.......................................................................................................................14 18. Buy Rimonabant Powder online................................................................................................. 14 (1) Buy Rimonabant Powder Questions & Answers................................................................. 15 (2) Rimonabant powder for sale...............................................................................................17 1. History of Rimonabant Rimonabant became available in UK in the beginning of July 2006 and by 2008, there were 56 countries where it was available. It was meant for people 1

2. Email: aas11@aasraw.com Whatsapp:+8618928439036 with a BMI greater than 30 or people whose BMI was greater than 27 but who had other risk factors like dyslipidemia and type 2-diabetes. In June 2006, European Commission approved its sale and it was submitted to FDA for US approval. However, FDA’s EMDAC voted against the drug, concluding that Sanofi-Aventis, the manufacturers of Rimonabant, had not demonstrated its safety effectively. In 2009, EMEA withdrew Acomplia, after suspending it in 2008, because of severe psychological side effects of the drug, such as suicidal tendencies. FDA never approved Rimonabant and therefore, it has never been marketed in the US. 2. Rimonabant Rimonabant is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite. Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world. Rimonabant is approved in 38 countries including the E.U., Mexico, and Brazil. It was rejected for approval for use in the United States. This decision was made after a U.S. advisory panel recommended the medicine not be approved because it may increase suicidal thinking and depression. 2

3. Email: aas11@aasraw.com Whatsapp:+8618928439036 3. Brand Name of Rimonabant Variations Other names for Rimonabant are Zimulti, Acomplia, Monaslim, Bethin, Riobant, Remonabent, Rimoslim and Riomont. 4. Rimonabant powder Product Name CAS Molecular Formula Molecular Weight Melt Point Storage Temp Color Rimonabant powder 168273-06-1 C22H21Cl3N4O 463.79 230-240ºC Refrigerator White or off white Crystalline powder 5. Mechanism of action-- Rimonabant powder Rimonabant is a specific CB1 cannabinoid receptor antagonist. There is considerable evidence that the endocannabinoid (endogenous cannabinoid) system plays a significant role in appetitive drive and associated behaviours. It is therefore reasonable to hypothesize that the attenuation of the activity of this system would have therapeutic benefit in treating disorders that might have a component of excess appetitive drive or over-activity of the endocannabinoid system, such as obesity, ethanol and other drug abuse, and a variety of central nervous system and other disorders. 6. How does Rimonabant powder work? • Rimonabant powder acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) 3

4. Email: aas11@aasraw.com Whatsapp:+8618928439036 metabolism, including adipose tissue, the liver, gastrointestinal tract and muscle2. • Rimonabant powder switches off the same brain circuits that make people hungry when they smoke cannabis. • CB1 receptor blockade with rimonabant powder acts to decrease the overactivity of the endocannabinoid system (EC system).3,4 The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance, as well as glucose and lipid (or fat) metabolism. 7. What is Rimonabant powder used for? • Rimonabant powder was studied to be used complementary to diet and exercise to treat obese or overweight patients who suffer from type 2 diabetes and abnormal levels of fat in the blood. • Sanofi argued that rimonabant powder could also prevent the risk of cardiovascular disease. • Patients with large waist circumference (102 cm in men and 88 cm in women) were said to most benefit from taking the drug. 8. Rimonabant for overweight or obesity Rimonabant is the first drug of a new class of medications that seems to reduce body weight and improve risk factors for diseases of the blood vessels and heart in people who are overweight or obese. We found four studies which evaluated weight loss, occurrence of disorders and adverse effects of treatment. The four studies involved 6625 people comparing rimonabant 20 mg with rimonabant 5 mg and placebo, in combination with a hypocaloric diet after one or two years of treatment. Greater weight loss and improvement in risk factors were seen after 20 mg of rimonabant. These results have to be 4

5. Email: aas11@aasraw.com Whatsapp:+8618928439036 interpreted with caution though, due to high discontinuation rates of study participants and the overall low quality of the included studies. We conclude that: average weight loss with rimonabant appears modest and more rigorous studies examining the efficacy and safety of rimonabant are required to fully evaluate the benefit risk ratio of this new drug. In Europe, rimonabant is contraindicated for patients with severe depression and/or patients who are treated with antidepressive medications. Rimonabant is furthermore not recommended for patients with other untreated psychiatric conditions. 9. Rimonabant powder dosage Rimonabant powder are taken by mouth. The recommended frequency of using Rimonabant powder is once daily. The maximum single dose of Rimonabant is 20mg. Rimonabant powder should be taken in the morning before breakfast. Regardless of obesity severity, Rimonabant powder should be taken every day. 5

6. Email: aas11@aasraw.com Whatsapp:+8618928439036 The maximum recommended duration of using Rimonabant powder is 24 months. • An adjustment of Rimonabant dosing regimen is not required in elderly patients under 75 years old. Patients over 75 years old should take Rimonabant powder with caution. • Reduction of Rimonabant daily dose is not required in patients with mild hepatic insufficiency. The reduction of Rimonabant single dose may be required in patients with moderate hepatic insufficiency. Patients with severe hepatic insufficiency should not take Rimonabant powder. • Change of Rimonabant powder dosage is not required in patients with mild and moderate renal diseases. If severe renal disease is diagnosed in a patient, he should refrain from the use of Rimonabant powder. • Adolescents under 18 years old were not involved in clinical and post-marketing studies of Rimonabant. powder should not be used as a long-term therapy of adolescent obesity. Therefore, Rimonabant If you want to buy Rimonabant powder online but have never taken these weight loss tablets, get to know the side effects and potential risks of Rimonabant powder. Before buying prescription, you can get the information about this weight loss drug by email. Rimonabant powder online no 10. Advantages of Rimonabant & the Rimonabant benefits This supplement has the following benefits: • It helps obese and overweight people to lose* weight in the safest and easiest way possible. Normally obesity and diabetes go hand in hand and the supplement also helps decrease* the symptoms of diabetes so that the user does not only cut weight but also gets relief from diabetes. 6

7. Email: aas11@aasraw.com Whatsapp:+8618928439036 • The supplement can be purchased online meaning that finding it is easier and it also comes with a 30 day money back guarantee. Therefore, if there is a problem with the product or if it does not work for you are assured of getting your money. • It also comes at an affordable price with small pills that can be easily swallowed. Only pill is recommended daily to achieve weight loss* so you do not have to worry about taking several pills a day and sometimes forgetting some doses. • The supplement comes packaged well and labeled clearly with all ingredients and their amounts. This enables the user to know exactly that what they are taking is clinically proven and to determine if they have any sensitivity to the ingredients in advance. • While using Rimonabant you do not need to starve yourself all go through painful and intense workouts. Normal house chores and walks are enough to give you effective results. 7

8. Email: aas11@aasraw.com Whatsapp:+8618928439036 11. The warning on Rimonabant Rimonabant is not recommended in pregnancy and is contraindicated in breast-feeding women.15 The SPC advises “caution” if the drug is used to treat patients with “moderate hepatic recommended in patients with “severe hepatic impairment” and should not be used in patients with “severe renal impairment”.15 The SPC states that rimonabant should not be started in patients with uncontrolled serious psychiatric illness such as major depression, and that appropriate treament for the psychiatric condition should be started first and rimonabant therapy considered once the condition is controlled. However, it also states that the use of rimonabant in combination with antidepressant medication is not recommended, because of limited data. impairment”. Rimonabant is not 12. Side effects of Rimonabant powder The side effects of Rimonabant powder are so many that they effectively counteract any positive effects that it may present. Even during the trials, it was reported that 1 patient out of every 8 dropped out of the said trials since the side effects became intolerable for them. The biggest and the most adverse effects, however, were psychological. Depression has come to get associated Rimonabant powder. This depression was so serious that it required medical treatment to be managed. Because of Rimonabant powder’s effectiveness against smoking, many people used it for smoking cessation and suffered from suicidal depression. as a severe side effect of Many patients experienced and reported extreme anxiety levels after taking Rimonabant powder. Nausea is another side effect which was so severe that it started interfering with the patients’ daily life. To summarize, the adverse side effects of Rimonabant powder are many – • Gastrointestinal Problems – One of the noted side effects are diarrhea, dry mouth, loss of appetite, nausea, vomiting and other gastrointestinal disorders. 8

9. Email: aas11@aasraw.com Whatsapp:+8618928439036 • Skin Problems – Excessive sweating and itching has been reported. • Musculoskeletal Problems – Joint sprains, back pain, inflammation and pain in the tendons, and spasms and cramps in muscles are common side effects. • Central Nervous System – Depression, memory loss, anxiety, mood changes, dizziness, diarrhea and sleep disorder. While experts speculate that if the dosage is lowered, some side effects may be managed but that still does not change the fact that the drug was never approved in the US because of the severity of its side effects. Also, the side effects that have been reported are rather serious which nullifies the drug’s positive effects against weight gain and smoking cessation. 13. Rimonabant Review You may be surprised by what I say in this Rimonabant review. We took the time to focus closely on the scientific studies, ingredients, side effects, and customer-service quality. Then we looked at user reviews from all over the internet. At last, we summarized the data we collected to give you the facts. (1) Safety– “Serious Health Concerns” Our first issue is the safety of the product. According to our Research Editor, “Post market analysis indicated a higher prevalence of suicidal thoughts and major depressions in patients treated with Rimonabant. The results were concerning enough to have approval revoked in a number of countries.” One dieter said, “I was in France when this was released and it worked great but I became severely depressed. How can you be that sad and losing weight?” Another claimed, “I was willing to try anything when I was at my heaviest. The side effects were brutal, nothing is worth feeling like that.” Others did not experience the debilitating depression as a side effect and had a more positive experience. One explained, “It worked great for me and I lost the weight I needed. I didn’t have a problem.” Another said, “I wasn’t as happy 9

10. Email: aas11@aasraw.com Whatsapp:+8618928439036 as I normally am while I was taking it but it worked so well I would totally use it again.” (2) Availability– “Not Approved in Most Countries” It is very difficult to find Rimonabant now because it has been banned in the countries where it was once available. One disappointed dieter said, “I loved it when I used it before but now I can’t find it anywhere!” Another complained, “I don’t understand why when something works that can’t be enough for everyone. They take away all the useful options.” Some were appreciative of the safety measures. One consumer said, “I liked that it worked so well but it was dangerous. I’m hoping the company tweaks the formula so I can get it again.” Another claimed, “I still have access to it so it isn’t as big of a deal to me. It isn’t easy but I can get it.” According to our research, safety and availability are two of the major concerns for dieters. If a product isn’t safe, it is difficult to trust that Rimonabant will lead to improved health overall and that ruins your chance of lasting results. (3) The Science – “Strong Clinical Support?” At DietSpotlight, we are primarily concerned with how effectively a product works. In the case of Rimonabant, the studies indicated it worked quite well for the majority of dieters. However, the science also shows that a greater number of participants had side effects that could have resulted in their death. This is simply unacceptable. 10

11. Email: aas11@aasraw.com Whatsapp:+8618928439036 14. Rimonabant tablet Recipe Rimonabant tablet is formulated from the following ingredients which are known to support rapid weight loss* in the body safely: • Rimonabant powder– This is the active ingredient in the supplement and also where it gets its name from. It helps in suppressing the user’s appetite and also increasing* metabolism in the body leading to increased rate of burning fat. • Meratrim – This is a clinically researched and approved ingredient that helps to lose* fat around the waist where most of the bad fat is contained. It ensures safe weight loss* and also that the user gets back into that attractive figure. • Chromium Polynicotinate – This is a combination of chromium and niacin and it increases* the absorption of the supplement into the user’s body. This ensures that the supplement works effectively. 11

12. Email: aas11@aasraw.com Whatsapp:+8618928439036 15. Does Rimonabant powder also aid smoking cessation? • Rimonabant powder (Zimulti in the US) was studied by Sanofi-Aventis as an aid to smoking cessation based on studies for up to one year in over 6,500 smokers motivated to quit smoking. • Sanofi-Aventis submitted a New Drug Application to the FDA, which in turn issued a non-approvable letter for rimonabant powder for use in smoking cessation. In June of 2007, the FDA's Endocrine and Metabolic Drugs Advisory Committee recommended against the approval of rimonabant powder due to concerns over serious side effects such as suicidality. 16. What were the results of Rimonabant powder clinical trial studies? • In clinical studies, Rimonabant powder was has been shown to improve a wide array of cardiometabolic risk factors as well as promoting sustained weight loss.5,6 • Approximately half of the observed improvement in HDL-cholesterol, triglycerides and HbA1C (an indicator of blood sugar control) in patients who received Rimonabant powder 20mg was beyond that expected from weight loss alone. • Serious psychological adverse effects, such as suicidality and depression led to the eventual global withdrawal of rimonabant powder by Sanofi-Aventis. 12

13. Email: aas11@aasraw.com Whatsapp:+8618928439036 17. Rimonabant for prevention of cardiovascular events (1) Background Blockade of the endocannabinoid receptor reduces obesity and improves metabolic abnormalities such as triglycerides, HDL cholesterol, and fasting blood glucose. We assessed whether rimonabant would improve major vascular event-free survival. (2) Methods This double-blind, placebo-controlled trial was undertaken in 974 hospitals in 42 countries. 18 695 patients with previously manifest or increased risk of vascular disease were randomly assigned to receive either rimonabant 20 mg (n=9381) or matching placebo (n=9314). Randomisation was stratified by centre, implemented with an independent interactive voice response system, and all study personnel and participants were masked to group assignment. The primary endpoint was the composite of cardiovascular death, myocardial infarction, or stroke, as determined via central adjudication. Analysis was by 13

14. Email: aas11@aasraw.com Whatsapp:+8618928439036 intention to treat. This study is registered with ClinicalTrials.gov, number NCT00263042. (3) Findings At a mean follow-up of 13·8 months (95% CI 13·6–14·0), the trial was prematurely discontinued because authorities in three countries about rimonabant. All randomised participants were analysed. At the close of the trial (Nov 6, 2008), the composite primary endpoint of cardiovascular death, myocardial infarction, or stroke occurred in 364 (3·9%) patients assigned to rimonabant and 375 (4·0%) assigned to placebo (hazard ratio 0·97, 95% CI 0·84–1·12, p=0·68). With rimonabant, gastrointestinal (3038 [33%] vs 2084 [22%]), neuropsychiatric (3028 [32%] vs 1989 [21%]), and serious psychiatric side-effects (232 [2·5%] vs 120 [1·3%]) were significantly increased compared with placebo. Four patients in the rimonabant group and one in the placebo group committed suicide. of concerns suicide by health regulatory in individuals receiving (4) Interpretation The premature termination of this trial has important lessons for drug development. A drug that was being marketed for weight loss, but being tested for improving cardiovascular outcomes, neuropsychiatric effects that was deemed unacceptable by regulatory authorities, and both the drug and the trial were abruptly terminated. induced a level of serious Also rimonabant drug, rimonabant production, rimonabant reddit,rimonabant clinical trials.rimonabant buy,rimonabant weight loss. Checkout: rimonabant fda,rimonabant china, rimonabant cb1, 18. Buy Rimonabant Powder online 14

15. Email: aas11@aasraw.com Whatsapp:+8618928439036 (1) Buy Rimonabant Powder Questions & Answers Q: What are the ingredients in Rimonabant? A: Rimonabant powder is the major ingredient contained in this drug. Q: What are the side effects of Rimonabant powder? A: Rimonabant can induce mental issues such as depression in the users. Furthermore, this drug is also known to induce suicidal tendencies in the user as well as abnormal changes in moods. Other side effects may include itching and excessive sweating. Q: How do I know if Rimonabant powder is right for me? A: Choosing the right product is the #1 question asked by DietSpotlight readers. We recommend trying any product before buying it and know that finding a product with a sample offer is near impossible - so we created our own product, Burn HD, with scientifically backed ingredients. Click here to get your sample of our powerful fat burner today. Q: Does Rimonabant powder work? A: Yes, the drug stood true to its claims and helped its users to reduce their appetite, thereby curbing obesity. Q: What is the price of Rimonabant powder? A: The price of Rimonabant is 2600/kg, USD350/100g. The min purity is 98%. 15

16. Email: aas11@aasraw.com Whatsapp:+8618928439036 Q: Where can I buy Rimonabant powder? A: You can order Rimonabant powder online at www.aasraw.com Q: How should I take Rimonabant powder? A: Rimonabant powder is available in a low dose of 5mg to a high dose of 20mg. Your need for it and how to administer it must come from the advice of a diet expert. Rimonabant powder is not set out to work alone. It is designed to be used in conjunction with proper diet and exercise to improve a person’s wellbeing while reducing the size of your waistline. Q: How do I contact Rimonabant customer service? A: • To contact us by our email inquiry system,or online skypecustomer service representative(CSR). • To provide us your inquired quantity and address. • Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA). • Payment done and the goods will be sent out in 12 hours(For order within 10kg). • Goods received and give comments. Q: Can I return Rimonabant powder? A: Yes, Rimonabant powder can be returned according to the return policy of its distributor or supplier. Q: What are the most common complaints about Rimonabant powder? 16

17. Email: aas11@aasraw.com Whatsapp:+8618928439036 A: Some consumers have raised complaints regarding the unsettling side effects of Rimonabant powder. (2) Rimonabant powder for sale There are a lot of weight loss products on the market, and Rimonabant powder is one of them, which is loved by many obese people. While Rimonabant powder is prohibited to use in many countries, but because of its powerful control appetite in order to reach the effect reducing weight, still have a large demand in the market, the corresponding Rimonabant powder suppliers will emerge. The well-known supplier is AASraw, the user feedback is very good, and has a great advantage in logistics. AASraw Biochemical Technology Co., Ltd., major at providing Anabolic Ster oids raw powder(Testosterone, Trenbolone, Boldenone,Nandrolone, Drostano lone, Methenolone, SARMS, etc), loss raw powder, Sex hormones raw powder. PCT drugs raw powder, Weight Buy rimonabant powder from AASraw, you can get: - High Quality With Competitive Price : 1) Purity: >99% 2) We are manufacturer and can provide high quality products with factory price. - Fast And Safe Delivery : 1) Parcel can be sent out in 24 hours after payment. Tracking number available 2) Secure and discreet shipment. Various transportation methods for your choice. 17

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