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Protein concentration (pg/ml)

GM-CSF. IL-6. VEGF. IL-8. 6. 4. 6. *. *. *. *. *. *. *. *. 30. 5. 5. 3. 4. 4. *. relative mRNA expression to unstimulated FLS. 20. 2. 3. 3. 2. 2. 10. 1. 1. 1. (ng/ml). 0. 1. 10. 100. 100. 100. 0. 1. 10. 100. 100. 100. 0. 1. 10. 100. 100. 100.

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Protein concentration (pg/ml)

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  1. GM-CSF IL-6 VEGF IL-8 6 4 6 * * * * * * * * 30 5 5 3 4 4 * relative mRNA expression to unstimulated FLS 20 2 3 3 2 2 10 1 1 1 (ng/ml) 0 1 10 100 100 100 0 1 10 100 100 100 0 1 10 100 100 100 rhAREG 0 1 10 100 100 100 (mg/ml) 0 0 0 0 10 100 0 0 0 0 10 100 0 0 0 0 10 100 genistein 0 0 0 0 10 100 ADAM17 AREG * 1.2 0 0 ng/ml * ** * 10 10 ng/ml 1.0 * 100 100 ng/ml 0.8 * relative mRNA expression to unstimulated FLS 0.6 Protein concentration (pg/ml) ** 0.4 0.2 (ng/ml) 0 1 10 100 100 100 rhAREG (mg/ml) 0 0 0 0 10 100 genistein IL-8 GM-CSF VEGF IL-6 200 1000 3000 160 800 2000 120 600 80 400 1000 40 200 0 0 0 A C B

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