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S. Lacey, K. Kennedy, R. Hancock, N. Esmen

Methodological Issues in CNS Neoplasm Incidence Tracing. J. Buchanich, A. Youk, G. Marsh, Z. Bornemann, F. Lieberman Center for Occupational Biostatistics and Epidemiology, University of Pittsburgh, Pittsburgh, PA. S. Lacey, K. Kennedy, R. Hancock, N. Esmen

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S. Lacey, K. Kennedy, R. Hancock, N. Esmen

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  1. Methodological Issues in CNS Neoplasm Incidence Tracing J. Buchanich, A. Youk, G. Marsh, Z. Bornemann, F. Lieberman Center for Occupational Biostatistics and Epidemiology, University of Pittsburgh, Pittsburgh, PA S. Lacey, K. Kennedy, R. Hancock, N. Esmen Division of Environmental & Occupational Health Sciences, University of Illinois at Chicago, Chicago, IL • Issues: • Geographic & temporal restrictions • Registry starts from 1935 to 2005 • Data confidentiality • Release of data for living & deceased cases • Case matching • Registry programming & systems limitations • Expense • Up to $8500 for cohort match • Registry application processes Purpose: To highlight methodological issues and obstacles encountered conducting cancer incidence tracing in the United States. These issues were encountered during a study which involved determining incident cases from multiple state cancer registries. Methods: • Conducted CNS cancer incidence tracing • 223,894 jet engine manufacturing workers • Traced from 1976 to 2004 in 24 states • Requested all CNS cancer matches • Date of diagnosis, histology, behavior, topography, residence at diagnosis and last known vital status • Identified issues and obstacles Registry Approval Process • Conclusions: • Despite some important limitations, cancer incidence studies of retrospective cohorts are feasible • Incidence studies require careful planning, strict attention to detail and organization • We urge state and regional cancer surveillance systems to give careful consideration to the benefits of a national repository for cancer incidence data Contact Information; For more information about this study, please contact Dr. Jeanine Buchanich at the University of Pittsburgh (jeanine@pitt.edu). Acknowledgments This study is being conducted in collaboration with the CT Department of Public Health and the University of Illinois at Chicago. We thank the employees, management, and union members as well as the Communications Facilitation Workgroup (CFW) for their continued support and contributions. Our progress would not be possible without their efforts.

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