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Introduction to Neurobiology & Channel Physiology

Introduction to Neurobiology & Channel Physiology. Neurobiology NST IB Questions. Methods, development & general Synapses, sensory transduction & processing Cutaneous sense Sensory feedback from muscle Posture Higher control of movement Special senses Higher cortical & limbic function.

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Introduction to Neurobiology & Channel Physiology

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  1. Introduction to Neurobiology& Channel Physiology

  2. Neurobiology NST IB Questions • Methods, development & general • Synapses, sensory transduction & processing • Cutaneous sense • Sensory feedback from muscle • Posture • Higher control of movement • Special senses • Higher cortical & limbic function

  3. Lecture topics • History and Philosophy • Electrical properties • Chemical properties • Neural determination • Vision • Hearing

  4. Discuss the Locatisation of function in the Cerebral Cortex

  5. Discuss the Locatisation of function in the Cerebral Cortex • History • Methods • Conculsion

  6. Types of evidence • Stimulation • Recording • Imaging • Lesion • Pharmacology • Microanatomy • Comparative • Developmental

  7. Channel Drugs • Glycosides (Ouabain, Digoxin) • Tetrodotoxin (TTX) • Tetraethylammonium (TEA), Caesium • Cyanide, Dinitrophenol (DNP)

  8. Channel studies • Extracellular electrode • Intracellular electrode • Voltage clamp • Patch clamp • Gene knockout • Sequencing, crystallography • Numerical simulation

  9. Channel comparisons V-gated Na V-gated K V-gated Ca Na/K pump channel channel channel 4 Subunits a a ab x1 x1 subunits Domains 4 4 4 Raises Ext [Ca] threshold Li+ passes not pumped CN, DNP Blocker TTX TEA glycosides

  10. Repeated firing Threshold Refractoriness Stability Conduction speed Subthreshold oscillations AP shape Charge movement H&H Predictions • Kinetic behaviour of channel

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