= c 1  N2s + c 2  Npz + c 3 (  a +  b +  c ) (1a 1 ) + 2 others (2a 1 and 3a 1 )

1. This is now one (group) orbital! • = c1N2s + c2Npz + c3(a + b +c) (1a1) + 2 others (2a1 and 3a1)

2. = c1Npx + c2Npy + c3(a - b) + c4(2a - b - c ) (1e) + another pair 2e

3. Homo is lone pair

4. Fundamentals of Molecular Orbital Theory

5. Acid-base and donor-acceptor chemistry Hard and soft acids and bases

6. Classical concepts • Arrhenius: • acids form hydrogen ions H+ (hydronium, oxonium H3O+) in aqueous solution • bases form hydroxide ions OH- in aqueous solution • acid + base  salt + water • e.g. HNO3 + KOH  KNO3 + H2O • Brønsted-Lowry: • acids tend to lose H+ • bases tend to gain H+ • acid 1 + base 2  base 1 + acid 2 (conjugate pairs) • H3O+ + NO2-  H2O + HNO2 • NH4+ + NH2-  NH3 + NH3 • In any solvent, the reaction always favors the formation • of the weaker acids or bases The Lewis concept is more general and can be interpreted in terms of MO’s

7. CO d+ d- C C C O O O M M Remember that frontier orbitals define the chemistry of a molecule CO is a a p-acceptor and s-donor

8. adduct base acid Acids and bases (the Lewis concept) A base is an electron-pair donor An acid is an electron-pair acceptor Lewis acid-base adducts involving metal ions are called coordination compounds (or complexes)

9. NH3 Frontier orbitals and acid-base reactions N-H s* Remember the NH3 molecule N-H s

10. Frontier orbitals and acid-base reactions Simple example of Acid/Base Reaction. Now more detail…

11. Frontier orbitals and acid-base reactions Simple example of Acid/Base Reaction. The protonation of NH3 again (Td) (C3v)

12. But remember that there must be useful overlap (same symmetry) and similar energies to form new bonding and antibonding orbitals What reactions take place if energies are very different?

13. Frontier orbitals and acid-base reactions Very different energies like A-B or A-E get reaction but no adducts form Similar energies like A-C or A-D adducts form A base has an electron-pair in a HOMO of suitable symmetry to interact with the LUMO of the acid

14. The MO basis for hydrogen bonding F-H-F-

15. Bonding e Non-bonding e As before…. MO diagram derived from atomic orbitals (using F…….F group orbitals + H orbitals)

16. But it is also possible from HF + F-, Hydrogen Bonding HOMO-LUMO of HF for s interaction Non-bonding (no symmetry match) Non-bonding (no E match) First form HF

17. The MO basis for hydrogen bonding F-H-F- LUMO HOMO HOMO First take bonding and antibonding combinations.

18. Similarly for unsymmetrical B-H-A Total energy of B-H-A lower than the sum of the energies of reactants

19. Good energy match, strong H-bonding e.g. CH3COOH + H2O Poor energy match, little or no H-bonding e.g. CH4 + H2O Very poor energy match no adduct formed H+ transfer reaction e.g. HCl + H2O

20. Ralph Pearson introduced the Hard Soft [Lewis] Acid Base (HSAB) principle in the early nineteen sixties, and in doing so attempted to unify inorganic and organic reaction chemistry. The impact of the new idea was immediate, however over time the HSAB principle has rather fallen by the wayside while other approaches developed at the same time, such as frontier molecular orbital (FMO) theory and molecular mechanics, have flourished.

21. The Irving-Williams stability series (1953) pointed out that for a given ligand the stability of dipositive metal ion complexes increases: It was also known that certain ligands formed their most stable complexes with metal ions like Al3+, Ti4+ and Co3+ while others formed stable complexes with Ag+, Hg2+ and Pt2+.

22. In 1958 Ahrland classified metal cations as Type A and Type B, where: Type A metal cations included: • Alkali metal cations: Li+ to Cs+• Alkaline earth metal cations: Be2+ to Ba2+• Lighter transition metal cations in higher oxidation states: Ti4+, Cr3+, Fe3+, Co3+• The proton, H+ Type B metal cations include: • Heavier transition metal cations in lower oxidation states: Cu+, Ag+, Cd2+, Hg+, Ni2+, Pd2+, Pt2+. Ligands were classified as Type A or Type B depending upon whether they formed more stable complexes with Type A or Type B metals:

23. Type A metals prefer to bind to Type A ligands and Type B metals prefer to bind to Type B ligands These empirical (experimentally derived) rules tell us that Type A metals are more likely to form oxides, carbonates, nitrides and fluorides, Type B metals are more likely to form phosphides, sulfides and selinides. This type of analysis is of great economic importance because some metals are found in nature as sulfide ores: PbS, CdS, NiS, etc., while other are found as carbonates: MgCO3 and CaCO3 and others as oxides: Fe2O3 and TiO2.

24. In the nineteen sixties, Ralph Pearson developed the Type A and and Type B logic by explaining the differential complexation behaviour of cations and ligands in terms of electron pair donating Lewis bases and electron pair accepting Lewis acids: Lewis acid   +   Lewis base            Lewis acid/base complex Pearson classified Lewis acids and Lewis bases as hard, borderline or soft. According to Pearson's hard soft [Lewis] acid base (HSAB) principle: Hard [Lewis] acids prefer to bind to hard [Lewis] bases and Soft [Lewis] acids prefer to bind to soft [Lewis] bases At first sight, HSAB analysis seems rather similar to the Type A and Type B system. However, Pearson classified a very wide range of atoms, ions, molecules and molecular ions as hard, borderline or soft Lewis acids or Lewis bases, moving the analysis from traditional metal/ligand inorganic chemistry into the realm of organic chemistry.

25. Hard Acids Hard Bases

26. Borderline Acids Borderline Bases

27. Soft Acids Soft Bases

28. Most metals are classified as Hard acids or acceptors. Exceptions: acceptors metals in red box are always soft . Solubilities: (S-H)AgF > AgCl > AgBr >AgI (S-S) But…… LiBr > LiCl > LiI > LiF Green boxes are soft in low oxidation states. Orange boxes are soft in high oxidation states.

29. Log K for complex formation hard soft softness

30. Most metals are classified as Hard acids or acceptors. Exceptions: acceptors metals in red box are always soft . Solubilities: (S-H)AgF > AgCl > AgBr >AgI (S-S) But…… LiBr > LiCl > LiI > LiF Green boxes are soft in low oxidation states. Orange boxes are soft in high oxidation states.

31. Chatt’s explanation: soft metals ACIDS have d electrons available for p-bonding Model: Base donates electron density to metal acceptor. Back donation, from acid to base, may occur from the metal d electrons into vacant orbitals on the base. Higher oxidation states of elements to the right of transition metals have more soft character. There are electrons outside the d shell which interfere with pi bonding. In higher oxidation states they are removed. For transition metals: high oxidation states and position to the left of periodic table are hard low oxidation states and position to the right of periodic table are soft Soft BASE molecules or ions that are readily polarizable and have vacant d or π* orbitals available for π back-bonding react best with soft metals

32. Tendency to complex with hard metal ions N >> P > As > Sb O >> S > Se > Te F > Cl > Br > I Tendency to complex with soft metal ions N << P > As > Sb O << S > Se ~ Te F < Cl < Br < I

33. The hard-soft distinction is linked to polarizability, the degree to which a molecule or ion may be easily distorted by interaction with other molecules or ions. Hard acids or bases are small and non-polarizable Hard acids are cations with high positive charge (3+ or greater), or cations with d electrons not available for π-bonding Soft acids are cations with a moderate positive charge (2+ or lower), Or cations with d electrons readily availbale for π-bonding The larger and more massive an ion, the softer (large number of internal electrons shield the outer ones making the atom or ion more polarizable) Soft acids and bases are larger and more polarizable For bases, a large number of electrons or a larger size are related to soft character

34. Hard acids tend to react better with hard bases and soft acids with soft bases, in order to produce hard-hard or soft-soft combinations In general, hard-hard combinations are energetically more favorable than soft-soft An acid or a base may be hard or soft and at the same time it may be strong or weak Both characteristics must always be taken into account e.g. If two bases equally soft compete for the same acid, the one with greater basicity will be preferred but if they are not equally soft, the preference may be inverted

35. Fajans’ rules • For a given cation, covalent character increases • with increasing anion size. F<Cl<Br<I • For a given anion, covalent character increases • with decreasing cation size. K<Na<Li • The covalent character increases • with increasing charge on either ion. • Covalent character is greater for cations with non-noble gas • electronic configurations. A greater covalent character resulting from a soft-soft interaction is related to lower solubility, color and short interionic distances, whereas hard-hard interactions result in colorless and highly soluble compounds

36. Examples • Harder nucleophiles like alkoxide ion, R-O–, attack the acyl (carbonyl) carbon. • Softer nucleophiles like the cyanide ion, NC–, and the thioanion, R-S–, attack the "beta" alkyl carbon

38. Further Development Pearson and Parr defined the chemical hardness, h, as the second derivative for how the energy with respect to the number of electrons. Expanding with a three point approximation Related to Mulliken electronegativity softness

39. Energy levels • for halogens • and relations between • , h and HOMO-LUMO energies