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Neurology Case Conference 4. Matematico Matias Maulion Medenilla Medina, K. Medina, S. Mejino. Clinical Impression. MENINGIOMA. Meningioma. Second most common primary tumor 15% of all primary intracranial tumors Mostly benign tumor Origin: arachnoidal ( meningothelial cap) cells
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Neurology Case Conference 4 Matematico Matias Maulion Medenilla Medina, K. Medina, S. Mejino
Clinical Impression MENINGIOMA
Meningioma • Second most common primary tumor • 15% of all primary intracranial tumors • Mostly benign tumor • Origin: arachnoidal (meningothelial cap) cells • particular from the arachnoidvilli • Women:Men (2:1) • Peak Age Incidence: 60th & 70th decades • Vascular Endothelial Growth Factor • Highly vascular, prominent surrounding edema
Etiology of Meningioma • Familial • Truncating mutations in the neurofibromatosis 2 gene (merlin) on chromosome 22q • Radiation Therapy • Previous Head Trauma • Estrogen and Progesterone receptors
Clinical Manifestations of Meningioma • Asymptomatic, Incidental finding • Irritation of the underlying cortex Seizures • Compression of the brain Localized or Non-specific headaches, Focal or Generalized Cerebral Dysfunction • Compression of the cranial nerves Focal Neurologic Deficits • Erosion, Invasion or Hyperostosis of Cranial bones • Narrowing, Occlusion of important cerebral arteries Transient ischemic attack (TIA)–like episodes or as stroke
Sites & Presentations of Meningioma 90% Intracranial 10% Intraspinal
Patient Correlation NING, PWEDE PO PAINSERT NG SALIENT FEATURES DITO…
Patient Correlation MENINGIOMA • Parasagittal/FalcotentorialMeningioma