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Basic molecular genetic mechanisms, part 2

Basic molecular genetic mechanisms, part 2. DNA replication Viruses. Addendum: DNA, replication and mutations. Proofreading exonuclease function. Viruses as models. Two basic shapes for viruses: rod and icosahedral. influenza virus with two surface proteins: H and N.

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Basic molecular genetic mechanisms, part 2

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  1. Basic molecular genetic mechanisms, part 2 • DNA replication • Viruses

  2. Addendum: DNA, replication and mutations

  3. Proofreading exonuclease function

  4. Viruses as models Two basic shapes for viruses: rod and icosahedral

  5. influenza virus with two surface proteins: H and N

  6. Genomics to ID pathogens: molecular forensics

  7. Boundaries between life and non-life: new extra large virus • Discovered during research into Legionellosis (cause Legionnaire's Disease). • Found in the water-borne amoeba Acanthamoeba polyphaga. • Human blood samples have also revealed antibodies for the virus. • Measurements: 800 nm long, 1.2 Mbp, 1260 genes. Only 10% is junk DNA. • Alive? Codes for 50 proteins never seen in viruses, include chaperones. • New family of ‘nucleocytoplasmic’ large DNA viruses, emerged with first life. • The 1.2-megabase genome sequence of Mimivirus. • Raoult D, Audic S, Robert C, Abergel C, Renesto P, Ogata H, La Scola B, Suzan M, Claverie JM. • Science. 2004 Nov 19;306(5700):1344-50.

  8. Mimivirus inside amoeba

  9. Mimivirus vs mycoplasma (U. urealyticum)

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