Chapter 11 Conceiving Children: Process and Choice

1. Chapter 11Conceiving Children: Process and Choice

2. Discussion question Do you want to have children? List the top three or four reasons for your choice.

3. Parenthood as an Option • More people than in the past are choosing to be “kid-free.” • In 2004, 19.3% of women age 40-44 were childless (compared with 9% in 1975) • Advantages of remaining childless • more time for self and companion • more financial resources • marriages less stressful • more spontaneity • more devotion to career

4. Parenthood as an Option (cont.) • Advantages to having children • children give & receive love • may enhance relationship • builds self-esteem, sense of accomplishment • greater meaning & satisfaction

5. Becoming Pregnant • Enhancing the possibility • intercourse just prior to or at ovulation • predicting ovulation • mucus, calendar, BT methods • ovulation-predictor urine tests--measure the rise in luteinizing hormone (LH) that occurs before ovulation (available OC). • Children conceived during the months of April and May have a high %age of abnormal genomes. Probable due to pesticides or fertilizers.

6. Infertility • Defined as inability to conceive after trying for 1 yr • Occurs in approx. 10-15% of U.S. couples trying to conceive • More than 6 months of trying --> consider consulting a health care practitioner • 60% of couples become pregnant after trying for 6 mos. • Can be due to male or female factors; both partners should be medically evaluated • Causes • Can be complex; often difficult to determine • Remain unidentified in as many as 15% of cases • Can be extremely emotionally painful for couples and pose challenges for their sexual happiness • Secondary infertility: inability to conceive a second child • Occurs in 10% of couples

7. Female infertility • Problems with ovulation • Hormone imbalances, severe vitamin deficiencies, poor nutrition • Emotional stress • Below-normal % body fat • Smoking, substance abuse • Can be treated w/medications that stimulate ovulation--can increase chance of multiple births • Damage to fallopian tubes • Previous infection • Endometriosis • Can sometimes be treated by surgery to remove scar tissue • Cervical mucus abnormalities • Presence of antibodies that attack sperm • Can form a plug that blocks passage of sperm • Can be treated by intrauterine injection of sperm

8. Male infertility • Contributes to 50% of cases; sole cause in 30% of cases • Problems w/sperm number • Abnormal sperm (poor motility, short lifespan) • Causes: • Inflammation in or abnormal development of testicles • Swollen vein in testis or vas deferens (varicocele) • Infectious diseases (mumps, STIs) • Smoking, alcohol & drug use • Cocaine use decreases spermatogenesis • Marijuana use slows sperm motility • Hormone disorder • Exposure to environmental toxins (chemicals, radiation) • Treatments: decrease frequency of ejaculation ( conc’n. of sperm), no hot baths, no tight shorts or long bike rides

9. Reproductive Alternatives & Technologies • Artificial insemination • Semen is mechanically placed in a woman’s vagina, cervis, or uterus (at home, or in a doctor’s office) • Donor semen can be used if woman does not have a male partner or partner’s sperm are inviable • Intrauterine insemination • Sperm is injected directly into uterus (helpful if female cervical mucus is a cause of infertility) • Surrogate mother • Woman who is impregnated (via artificial insemination or IVF) by an infertile or childless couple; carries baby to term and gives it to the couple for adoption

10. Reproductive Alternatives & Technologies (cont.) • In vitro fertilization (IVF) • Mature eggs are harvested from woman’s ovary • Eggs are fertilized by sperm in a laboratory • Embryos are introduced into woman’s uterus • Intracytoplasmic sperm injection (ICSI) • When a single sperm is injected into an egg • May be a part of in vitro fertilization if semen is of poor quality or quantity

11. In vitro fertilization  Ovaries are stimulated with hormones to produce multiple ova • 1st “test tube baby” born in England in 1978 • In U.S., ~48,000 babies born each year from IVF • Success rate: almost 30%  mature eggs are harvested from ovary and fertilized in a laboratory dish by partner’s or donor’s sperm  fertilized eggs are allowed to divide to 2- to 8-cell stage  Embryos are introduced into woman’s uterus

12. Financial and health costs of reproductive technologies • Financial costs • One IVF procedure: $12,000 - $14,000, • Intrauterine injection (IUI): $500-$700 • Multiple attempts are often needed • If donor eggs, sperm, or ICSI are needed, adds to cost • Health costs • Multiple embryo pregnancies are riskier • For mothers: C-sections, high b.p., greater complications during birth • For babies: miscarriage, prematurity, low birth weight, birth defects

13. Pregnancy detection • First signs: light period, spotting, or no period • Implantation bleeding (6-12 days post-conception) • Tender breasts • Fatigue • nausea/vomiting; appetite change • “morning sickness” typically begins 2-8 weeks post-conception and lasts around 6-8 weeks • Some women feel none; some feel sick their whole pregnancy • blood or urine tests for human chorionic gonadotropin (HCG), secreted by placenta • Most sensitive blood tests can detect 7 days post-conception • Headaches, backaches • Food cravings, enhanced odor sensitivity

14. Spontaneous abortion (miscarriage) • Definition: spontaneous expulsion of fetus from the uterus in 1st 20 weeks of pregnancy • Frequency • 10-25% of all known pregnancies • Estimated 50-75% of unknown pregnancies (miscarriage isn’t felt b/c it occurs before the woman gets her period) • Causes • Rejection of abnormal fetus, implantation problem • Hormonal problem, infection, or other health problem/trauma • Smoking, substance abuse • Timing: usually occur before 13 weeks (in 1st trimester) • Symptoms: heavier-than-usual menstrual flow (early miscarriage) to cramping, contractions, heavy bleeding (later miscarriage) • Rarely means that a later pregnancy will be unsuccessful • Can be emotionally traumatic; couple may need to grieve

15. Elective abortion • Decision to terminate a pregnancy by medical procedures • In U.S., 3 million unplanned pregnancies/yr. • 48% of women w/unintended pregnancies were using contraception during the month they became pregnant (though often not correctly each time) • Of these, 1.3 million pregnancies result in abortion • 43% of women in U.S. will have had an abortion by age 45 • Socioeconomic factors • Unintended pregnancy has increased by 29% among poor women while decreasing 20% among higher-income women. • Low-income women are >4x as likely to have an unplanned pregnancy, due to cuts in government-funded contraceptive services

16. When abortions are performed ~10% are performed after 1st trimester ~1% after 20 weeks Source: Centers for Disease Control and Prevention. Strauss, Lilo T., Herndon, Joy, Chang, Jeani, Parker, Wilda Y., Bowens, Sonya V., Berg, Cynthia J. 2005. Abortion Surveillance United States, 2002. Morbidity and Mortality Weekly Report.

17. Abortion procedures • Medical abortion (RU486): • up to 7 weeks of pregnancy •  Woman takes mifepristone (RU486) •  RU486 works by blocking progesterone, causing cervix to soften, uterine lining to break down, and bleeding to begin •  A few days later, second drug is taken that causes uterus to contract to expel any remaining fetal tissue • available in Europe since 1980; in U.S. since 2000

18. Abortion procedures (cont.) • Suction curettage: 7-13 weeks • Under local anesthetic, cervical os is dilated slightly, and a small vacuum tube is inserted to draw out fetal tissue, placenta, and uterine lining • Dilation and extraction: 13-21 weeks • Requires general anesthetic • Uses suction, forceps, and curette (metal instrument used to scrape the walls of the uterus) • Intact dilation and evacuation, or late-term abortion: after 20 weeks, before viability at 24 weeks • Cervix is dilated, fetus emerges feet-first, fetal skull is collapsed to permit passage of the head through cervix and vagina

19. Abortions per 1,000 women 30 25 20 15 10 5 0 1973 1975 1977 1979 1981 1983 1985 1987 1989 1991 1993 1995 1997 1999 2001 Abortion Rates Among Women Aged 15–44 • Decline due mainly to increased use of long-acting hormonal contraceptn., decreased pregnancy rates among teenagers, and increased use of emergency contraception. Source: Finer and Henshaw, 2005

20. Contraceptive Risk-taking and Abortion • Over half of women who had an abortion were using contraception when they became pregnant • Other unintended pregnancies are often the result of contraceptive risk-taking--not using a contraceptive consistently or reliably • What contributes to contraceptive risk-taking? • Being under influence of alcohol or drugs • Feeling guilty about sex • Women who lack strong self-esteem often fear alienating a partner by asking for his cooperation w/birth control • Women who have experienced abuse are twice as likely to have an unintended pregnancy

21. Abortion rates in developed world:factors • U.S. has one of the highest abortion rates in the developed world • Factors commonly found in countries w/lower rates of abortion • Comprehensive sex education in schools • Easy access to inexpensive or free birth control and emergency contraception • Social and health services to women and children

22. Correlation between abortion rate & access to contraception • EX: Soviet Union • Trade opens w/Western world in 1988, and modern contraceptives arrive in Soviet Union • 1992: Russian government began subsidizing family planning services and distributing free contraceptives

23. Abortion legality and rates Source: Guttmacher Institute (www.guttmacher.org)

24. Illegal abortion • 25% of women worldwide live in countries where abortion is illegal • Illegal abortion procedures are extremely unsafe • Some women try to self-induce abortions by using enemas, laxatives, pills, herbs, and other substances • Illegal abortionists usually insert a catheter or sharp instrument into the uterus to induce contractions. • Account for 150,000-200,000 maternal deaths/yr. • In Latin America, where legal abortion is restricted to rape or endangerment of woman’s life, almost half of maternal deaths are due to illegal abortion (WHO) • Globally, illegal abortions account for 21% of all maternal deaths

25. Long-Term Safety of Abortion • First trimester abortions pose virtually no future risk of: • Infertility • Ectopic pregnancy • Miscarriage • Birth defect • Preterm or low-birth-weight delivery • There is no association between abortion and breast cancer. • Abortion does not pose a hazard to women’s mental health. • Research studies continue to find that abortion is no more likely to cause mental health problems than is continuing an unwanted pregnancy. Source: Boonstra, 2006

26. U.S. Abortion controversy & legal history • Early American law, based on English common law, allowed abortion until quickening (btwn 18-24 weeks) • 1860s: abortion made illegal except to save woman’s life • 1860-1970s: • Rich women traveled to country where abortion was legal or paid a U.S. physician to perform an illegal abortion • Women w/o money may have found access to underground skilled abortion providers who worked for free or very little • Otherwise: “back alley” abortions using unsafe procedures, or dangerous self-induced abortions (wire coat hanger, douching w/bleach, swallowing turpentine) • 1973: Roe v. Wade legalized right to abortion before viability (~24 weeks) • 1977: Hyde Amendment: restricted federal Medicaid funds for abortions

27. U.S. Abortion controversy & legal historymore recent issues • Gag rule: • Banned federal funds for family planning clinics that inform women about abortion as part of counseling • Reversed by Clinton administration • Global gag rule: • Cut off aid to international health programs involved in any abortion-related activities, including info & referral • Establised by Reagan in ‘84, reversed by Clinton, reinstated by GW Bush in ‘01 • Access to family planning & abortion clinics • Freedom of Access to Clinic Entrances Act (1994): prohibits use/threat of or physical obstruction to prevent access to reproductive health care services

28. Abortion controversy in U.S. • 55-65% of Americans believe women should have access to legal abortion • Public opinion about Roe v. Wade: • 63% want it to remain in place • 23% want it overturned • Anti-abortion/pro-life groups believe that life begins at conception • Pro-choice groups see abortion as a necessary last resort • Many people who believe abortion is wrong also believe that women should still have access to safe, legal abortion (“abortion should be safe, legal, and rare”)

29. Abortion in the U.S.: current restrictions • Bush administration has supported implementing restrictions on abortion at the state level • Current restrictions as of 2006: • 32 states require mandatory counseling session • 24 states also require 24-hr waiting period btwn counseling session and abortion • 4 states restrict private insurance from covering abortion unless woman buys additional policy for that purpose • 21 states unnecessarily require abortion to be performed in a hospital instead of a clinic after a certain number of weeks of pregnancy (and in some of these states, only clinics perform abortions, not hospitals) • 34 states have parental consent laws that require a minor to obtain one or both parents’ consent before she can have an abortion

30. Discussion question: States with the most restrictions on abortion: typically provide the fewest resources for mothers and children often mandate that abstinence be stressed in sex education curricula Why do you think this is the case?

31. Pregnancy

32. the pregnant woman’s experience • Wide range of positive and negative emotions • Women often feel “guilty” about experiencing any negative feelings • Emotions are affected by physical changes • First trimester: increased fatigue, nausea, and breast changes • Second trimester: movement felt; heightened sense of well-being • Third trimester: increased size; greater discomfort • Emotions are influenced by life factors • How decision for pregnancy was made • Current/impending lifestyle changes, career, etc. • Relationship issues • Financial resources • Hopes and fears about parenthood At 9 mos.

33. Pregnancy: the partner’s experience • Also may have a wide range of positive and negative emotions • May feel ecstatic • May feel fearful about future mom’s and baby’s well-being • May feel nervous about impending birth and his/her ability to “keep it together” • Common to feel some concern over impending increase in financial responsibility • Possible feelings of separation from partner, from experience of pregnancy • May experience some psychosympathetic symptoms, such as nausea, fatigue

34. Sexual activity during pregnancy • Sexual activity and orgasm are safe throughout pregnancy until labor begins, unless there are risk factors • Pregnant woman’s sexual interest may change during pregnancy • Some women experience increase in desire • Some women experience changes in lubrication, ability to reach orgasm • Nausea and physical discomfort may negatively impact a woman’s desire--especially in 1st & 3rd trimesters • Modified sexual positions are often needed • Side-by-side, woman-on-top, sitting, rear-entry are all good options

35. Fetal Development • 40 week gestation, measured from LMP • Divided into 3 trimesters each 13 weeks. • Immediately after fertilization: • Zygote: single cell resulting from union of sperm & egg cells • Blastocyst: multicellular ball of cells that implants on uterine wall 1-2 weeks after fertilization

36. First trimester development • Zygote  blastocyst  implantation on uterine wall 1-2 weeks after fertilization • 9-10 weeks after LMP: can detect heartbeat • 8 weeks: spinal canal, beginning of arms/legs, eye buds, fingers/toes, • 3rd month: internal organs begin to form (heart w/4 chambers, kidneys, etc.) ~2.5 in. 1 mo. 2 mo. 3 mo.

37. Second trimester development • 4th month: sex can be distinguished, external body parts are clearly formed (eyebrows, eyelashes, etc.) • Fetal movements can be felt by mother by end of 4th month • Period of growth, organ maturation, fat deposition, muscle development, bones begin to become solid • By end of second trimester, fetus can open its eyes 4 mo. 5 mo. 6 mo.

38. Third trimester development • Fetus continues to grow • Hearing, ability to sense changes in light develop in 7th mo.; brain & nervous system become more functional in 8th mo. • Increases in weight from ~4lbs to average of 7 lbs. at birth • Skin changes from wrinkled to smooth • At birth, fetus is covered w/a protective creamy, waxy substance called the vernix caseosa 7 mo. 8 mo. 9 mo.

39. Prenatal care • Before pregnancy: • HIV test, German measles (rubella) immunity • During pregnancy: • Good nutrition, adequate rest, routine check-ups, exercise, childbirth education • Risks of poor prenatal care: • Low birth weight, lung disorders, brain damage, abnormal growth patterns • Lifelong effects • Increased chance of maternal complications • In U.S., 4x as many African American women as white women die from childbirth complications due to poor access to prenatal care • Risk of dying from pregnancy/childbirth in N. America: 1 in 3,700 (0.02%) • Risk of dying from pregnancy/childbirth in Asia: 1 in 65 (1.5%) • Risk of dying from pregnancy/childbirth in Africa: 1 in 6 (16.7%)

40. Risks to fetal development • Fetus depends on mother for nutrients, oxygen, and waste elimination--substances pass through the placenta: • Disk-shaped organ attached to the uterine wall and connected to fetus by the umbilical cord; substances pass btwn mother and fetus through the placental cell walls • Placenta prevents some, but not all, bacteria and viruses from passing into fetus circulatory system--many, include HIV, can cross • Nicotine, prescription & nonprescription drugs, alcohol • Alcohol can cause birth defects. • Fetal alcohol syndrome (FAS): syndrome in infants caused by heavy maternal prenatal alcohol use; characterized by heart defects, brain damage, physical malformations, and below-normal IQ • Babies can be born addicted to alcohol/drugs • Toxic chemicals and pollutants in the environment • Nicotine/smoking reduces oxygen, increases the chance of miscarriage & pregnancy complications

41. Close-up view of placenta (Fig. 11.7) • Fetal blood circulates independently within closed system of the fetus and inner part of placenta • Maternal blood flows in uterine walls and through outer part of placenta • Fetal and maternal blood does not intermingle, but some substances (nutrients, waste products, drugs, microbes, can pass through walls of blood vessels)

42. Ultrasound imaging • First trimester: ultrasound & blood tests are typically performed at 12 wks • 20 weeks (halfway): 2nd ultrasound to examine organ development; can identify sex if parents want to know Nuchal fold translucency measurement During 12-week ultrasound

43. Pregnancy after 35 • Most healthy women from age 35 into their 40s have healthy pregnancies--if problems do arise, they can usually be successfully treated. • Quite common now--20% of all childbearing women in U.S. • Women over age 35 have an increased risk of: • Fertility problems • Multiple pregnancy (twins or more) • Fetus w/abnormal chromosome # (often results in miscarriage--see slide on abnormal chromosome #) • Premature delivery • Cesarean section delivery • Placenta previa, a condition in which the placenta is in the wrong place and covers the cervix • Chronic illnesses such as high blood pressure or diabetes that are important factors during pregnancy

44. Usually done at 14-16 wks. Cells must be cultured for several weeks before tests can be done. Can be done at 8-12 wks. Can perform tests on cells immediately. Amniocentesis vs. CVS Fetal cells taken from placenta Fetal cells taken from amniotic fluid Chorionic villus sampling (CVS) Amniocentesis Needle inserted through abdomen to extract amniotic fluid Ultrasound monitor Ultrasound monitor Suction tube inserted through cervix to extract chorionic villus tissue from the placenta Fetus Fetus Placenta Placenta Uterus Chorionic villi Cervix Cervix Uterus Amniotic fluid Centrifugation Fetal cells Fetal cells Biochemical tests Several hours Several weeks Karyotyping

45. 5,000 Abnormal chromosome number in humans • In most cases, abnormal chromosome number in a human embryo will result in miscarriage. • A few examples of abnormal chromosome number produce viable births; some of these babies have other symptoms, some don’t. • Trisomy 21, or Down syndrome • Abnormal # of sex chromosomes • XXY, XYY, XXX, XO

46. An extra copy of chromosome 21 causes Down syndrome (trisomy 21) • Trisomy 21 is the most common chromosome # abnormality (~1 in 700). • Symptoms: • characteristic facial features. • short stature. • heart defects. • susceptibility to respiratory infections, leukemia, and Alzheimer’s disease. • Reduced life span. • Varying degrees of mental retardation.

47. 90 80 70 60 Infants with Down syndrome (per 1,000 births) 50 40 30 20 10 0 35 40 50 20 25 30 45 Age of mother The chance of having a child with Down syndrome increases with maternal age • Why is this? • Due to a peculiarity of meiosis (the cell division that forms gametes such as eggs and sperm) in female mammals. • In the female ovary, egg cells are arrested in the middle of the cell division process until time of ovulation (could be decades later!). • The longer the cells are arrested in this state, the greater the chance of an error in distribution of chromosomes to each egg cell. Figure 8.20C

48. Contemporary childbirth • Parents-to-be work as a team • Childbirth education classes provide information about what to expect in labor and birth, breathing/relaxation techniques, and possible medical interventions • Women assisted by a birth attendant during labor had fewer C-sections, less pain medication, shorter labor, and greater satisfaction w/birth experience • Birthplace options: home, birthing center, hospital w/midwife or w/ob-gyn

49. Labor • Walking during labor can help progression of labor • Positions: • Lying on back is the worst • Birthing balls, warm bath, massage can help • Episiotomy: • surgical incision in the perineum to enlarge the vagina during birth • Previously thought to be easier to sew up than a “natural tear” • Now shown to be associated w/greater tearing • Medically unnecessary, cause more harm than good.

50. First-stage labor • Longest of the 3 stages • Avg: 10-16 hr for 1st birth; • 4-8 hr in subsequent births • Effacement(thinning and flattening) of the cervix is completed (latent) • Regular contractions begin • Cervix dilates to 10 cm • early labor (latent) (up to 4 cm) • active labor (4-8 cm) • transition (8-10 cm) • Amniotic sac often ruptures (“breaking bag of waters”)