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Methylation Status of AKAP12β Promoter in Human Astrocytomas

This study examines AKAP12β promoter methylation in human astrocytomas, showing higher methylation levels in WHO grade II-IV diffuse astrocytomas compared to grade I pilocytic astrocytomas, although statistical significance is not reached. The average methylation percentage is graphed for each sample. Normal brain, pilocytic astrocytoma, WHO II-III astrocytomas, primary GBM samples, and GBM cell lines are included.

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Methylation Status of AKAP12β Promoter in Human Astrocytomas

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  1. Supplemental Figure 5. AKAP12β promoter methylation status in human astrocytomas. There is a trend for increased AKAP12β promoter hypermethylation in diffuse human astrocytomas of WHO grade II-IV as compared to WHO grade I pilocytic astrocytomas although not reaching statistical significance. The average percentage of methylation is plotted for each sample of the AKAP12β promoter region. Horizontal bars represent average methylation values for each group. Normal brain (NB), pilocytic astrocytoma (PA), astrocytomas (WHO II-III) / primary GBM samples (GBM) and GBM cell lines (CL).

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