1 / 60

組織再生 Tissue Regeneration

Biomaterials and Tissue Engineering Laboratory Fu Jen Catholic University. Liu HW Lab. 組織再生 Tissue Regeneration. 劉席瑋 Hsia-Wei Liu. 輔仁大學生命科學系助理教授 中研院物理所訪問學者 工研院材化所研究員 長庚醫院骨科博士後研究員 國立清華大學化工博士 / 醫學工程碩士. 全球生技產業概況 --- 全球醫療趨勢. 我國生技產業現況. 甚麼是再生醫學 ?. 甚麼是組織工程 ?. 構成個體的層次. 循環系統. 呼吸系統. 消化系統.

halia
Download Presentation

組織再生 Tissue Regeneration

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Biomaterials and Tissue Engineering Laboratory Fu Jen Catholic University Liu HW Lab 組織再生Tissue Regeneration 劉席瑋 Hsia-Wei Liu 輔仁大學生命科學系助理教授 中研院物理所訪問學者 工研院材化所研究員 長庚醫院骨科博士後研究員 國立清華大學化工博士/醫學工程碩士

  2. 全球生技產業概況---全球醫療趨勢

  3. 我國生技產業現況

  4. 甚麼是再生醫學?

  5. 甚麼是組織工程?

  6. 構成個體的層次

  7. 循環系統 呼吸系統 消化系統 泌尿系統 骨骼肌肉系統 免疫系統 神經系統 內分泌系統 生殖系統 皮膚系統

  8. Why is it Important? • Birth Defects (genetic mutations)

  9. Why is it Important? • Burn Victims

  10. Why is it Important? • War Injuries

  11. Why is it Important? • Sports Injuries

  12. 器官，不要再等了！

  13. 侏儸紀公園 When mosquito meets dinosaur 

  14. AMBER ? ? ?

  15. I am there

  16. ?

  17. A cell that has the ability to continuously divide and differentiate (develop) into various other kind(s) of cells/tissues 幹細胞(Stem Cell)

  18. Stem cells are the base cells of the body. The different tissues form out of them – skin, muscles, bones, blood, nerve fibres, and all the organs.

  19. Stem Cell Transplant Research, Parkinson's Disease

  20. Stem cells used to boost breasts

  21. 明尼蘇達大學這批科學家由朵瑞絲泰勒博士（Dr. Doris Taylor）領軍，他們從捐贈者遺體取出心臟，在實驗室以界面活性劑洗去心臟細胞，取得有「鬼心」（ghost heart）之稱的膠原蛋白支架。再將取自需換心者的數百萬顆年輕幹細胞注入支架，假以時日，這群幹細胞會附著上支架、分裂至特定數量，心臟即能自主搏動。

  22. 使年輕;使恢復精神

  23. 組織工程基本原理Basic principles of tissue engineering Cells expansion Growth Factors Cells isolation Biomaterials 3-D Scaffold In vivo implantation In vitro culture

  24. 組織工程三要素 細胞 支架 生長因子

  25. 幫細胞蓋一個家…組織工程用支架

  26. Scaffolds • Various textures and materials • Encourage cells to grow • Allow nutrients to permeate • Won’t harm the patient

  27. Tissue Engineering • Generation of semi-synthetic tissues and organs • Biocompatible scaffolding materials • Synthetic polymer or natural material (e.g. collagen) • Living cells grown in culture • Fully differentiated cells • From simple tissues and organs (skin, cartilage, urinary bladders) to whole organs using stem cells

  28. Metals Ceramics Polymers Semiconductor Materials Skin/cartilage Drug Delivery Devices Ocular implants Bone replacements Orthopedic screws/fixation Heart valves Synthetic BIOMATERIALS Dental Implants Dental Implants Biosensors Implantable Microelectrodes

  29. Biomaterials cover all classes of materials – metals, ceramics, polymers

  30. Uses of Ceramics • Structural components • Joint replacements, hip and knee • Spinal fusion devices • Dental crowns, bridges, implants, etc • Other applications • Inner ear and cochlear匙形implants • Tissue engineering • Coatings for heart valves

  31. Engineering bone grafts • Change stem cells into bone cells • with proper growth factors in cell culture media • This scaffold can’t be too big or the cells inside will die since they will not get enough oxygen A 3D calcium phosphate scaffold From Becton Dickinson

  32. Uses of Metals • Structural components • Joint replacements • Bone fracture pins, plates • Dental implants • Other applications • Leads, wires, tubing • Cardiac devices

  33. Artificial Hip Joints http://www.totaljoints.info/Hip.jpg

  34. Uses of Polymers • Many applications • Valves, ducts, catheters • Joint replacement • Coatings, encapsulants • Tissue engineering scaffolds • Lenses

  35. Intraocular Lens 3 basic materials - PMMA, acrylic, silicone

  36. Vascular Grafts

  37. Uses of Biological Materials • Scaffolds • Replacement tissues • Skin, cartilage, etc. • Coatings for synthetic polymeric or metallic materials • Plastic/cosmetic surgery

  38. Substitute Heart Valves

  39. Artificial Vessels • Usually for by-pass operation http://popularmechanics.com/popmech/sci/tech/9805TUMDOM.html

  40. A new bladder • To make a bladder one need a scaffold and several different type of cells

More Related