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Le CRNH-IdF Centre de Recherches en Nutrition Humaine d’Ile de France Alain GRYNBERG

Le CRNH-IdF Centre de Recherches en Nutrition Humaine d’Ile de France Alain GRYNBERG. Clinical investigation. Epidemiology (INRA-INSERM-Paris13). Basic science. Gut, satiety digestion CRV ( Avicennes ). 150<employees<200. CV risk diabetes ( Jean Verdier). Publications>100/y.

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Le CRNH-IdF Centre de Recherches en Nutrition Humaine d’Ile de France Alain GRYNBERG

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  1. Le CRNH-IdFCentre de Recherches en Nutrition Humained’Ile de FranceAlain GRYNBERG

  2. Clinical investigation Epidemiology(INRA-INSERM-Paris13) Basic science Gut, satietydigestionCRV(Avicennes) 150<employees<200 CV risk diabetes(Jean Verdier) Publications>100/y Obesity centergenotyping (La Pitié) Adiposetissue(INSERM, Paris 6) Protein, satiety digestion (INRA, AgroParisTech) Food economy (INRA)

  3. UMR U557 /U1125S Hercberg SMBH-UP13 UMR Inserm U872 K ClémentUP6 Scientificcouncil Direction COPIL Gastroenterology-HepatologyR BenamouzigAVC-UP13 NutritionJM OppertLPS-UP6 Endocrinology-DiabetologyG Reach AVC-UP13 GenotypingK ClémentAmbulatory ExplorationJM Oppert LPS-UP6 compliance CRVR BenamouzigAVC-UP13 Clinicalinvestigations Endocrinology-diabetology-NutritionP ValensiJV-UP13 U914 D Tome Agroparistech Gut, satiety Risk factors Obesity / AdT URA 1303 ALISS LG SolerINRA Ivry Epidemiology Economy

  4. Scientific Activity 1 Dietary behaviour &food consumption General population dietary behaviour and consumption Specific populations children, elderly, socio-demographic and socio-economic categories, diseased populations Variability evolution of behaviour , regional variations Typologies food consumption data collection & new tools design, methodology for global nutrition and creation of dietary typologies

  5. Scientific Activity 2 Determinant factors of behaviour on food consumption & nutritional status costs vs nutritional quality, socio-economic level, food supply vs demand economical social taste training, food acceptability, lifestyle, life cycles, … hunger & satiety, satiety in the course of meal, attitudes and beliefs, energy density in food, portion size, conviviality & stimuli sensorial psycho-physiological initiation and stop of eating, mechanisms of nycthemeral periodicity; conditioning and training physio-pathological physical activity, physiological and pathological situations

  6. Scientific Activity 3 Dietary behaviour & health Quality of life Physiological functions hormonal, cardiovascular, adipose, digestive Risk factors overweight, HTA, dyslipidemia, metabolic syndrome Morbi-mortality Interactions genetic factors / risk factors / behaviour

  7. Scientific Activity 4 Prevention strategies Market & behaviour • Effects of information on behaviour & corpulence • Effects of information and product characteristics on food choices • Education strategies for health considering population specificities. • Compliance to nutritional recommendations Social marketing of information Transfer to population

  8. Main clinical explorations availablein Paris-13 sites • AvicennePr R Benamouzig, Dr G AirineiGastro-entero-hepatology • 300 m2 heavy clinical exploration • Body composition • Ambulatory and resting energy expenditure • Qualitative and quantitative analysis of dietary behaviour • Metabolic & hormonal profile • Behaviour study boxes • Intestinal perfusion coupled to stable isotope tracers • Gut motility and gastric emptying (stable isotopes-echography) • Digestive tract biopsies, faecal and colonic flora Indirectcalorimetry biphotonicabsorptiometry stable isotope tracers

  9. Main clinical explorations availablein Paris-13 sites Arterial compliance endothelial function • Jean Verdier HospitalPr Paul Valensi, Pr Emmanuel CossonEndocrinology, CV riskfactors • Body composition • Ambulatory and resting energy expenditure • Qualitative and quantitative analysis of dietary behaviour • Metabolic & hormonal profile • Insulin-resistance coupled to calorimetry • Insulin secretion and sensibility to insulin • Peripheral endothelial function, artery compliance and CV autonomic activity • CV activity & echocardiography • Non invasive AGE measurement • Continuous glycaemic profile (G-Holter) Body composition Microcirculation by laser doppler

  10. Main clinical explorations available in Paris 6 site La Pitié SalpétrièrePr JM Oppert, Pr K. Clément Obesity, adipose tissue • Unit of ambulatory exploration in obesity • Ambulatory and resting energy expenditure • Body composition • Qualitative and quantitative analysis of dietary behaviour • Metabolic & hormonal profile • Exercice training for obese patients • Adipose tissue phenotyping • Functional genomic • Genetic epidemiology, mutations & polymorphisms

  11. AVC CRNH IdF LPS JV LPS JV AVC The Projet : Phenotyping Harmonization technicalprotocols& equipmentharmonization Body composition Hormonal & metabolic profile endothelialfunctionglycaemicprofile Free livinginvestigations RhoneAlpes Ouest IdF Auvergne

  12. The Projet : Scientific Development • Diabetes, CVD • Subclinical cardio-vascular changes in the alterations of vago-sympathetic balance in prediabetes • Postprandial changes in the vago-sympathetic balance across the glycemic continuum from normoglycemia to prediabetes and diabetes • Geographic origin, psycho-social deprivation and diet as predictive factors for gestational diabetes mellitus • Digestion, Satiety • Microbiota • Quality of the source of proteins • Obesity • Microbiota

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