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Sofosbuvir + Ribavirin in HCV- HIV Coinfection: HCV GT 1,2,3,4 PHOTON-2 Trial

Phase 3. HIV Coinfection. Treatment Naïve and Treatment Experienced. Sofosbuvir + Ribavirin in HCV- HIV Coinfection: HCV GT 1,2,3,4 PHOTON-2 Trial. Molina JM, et al. IAC. 2014; Abstract MOAB0105LB. Sofosbuvir plus Ribavirin for HCV-HIV Coinfection PHOTON-2 Trial: Study Features.

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Sofosbuvir + Ribavirin in HCV- HIV Coinfection: HCV GT 1,2,3,4 PHOTON-2 Trial

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  1. Phase 3 HIV Coinfection Treatment Naïve and Treatment Experienced Sofosbuvir + Ribavirin in HCV-HIV Coinfection: HCV GT 1,2,3,4PHOTON-2 Trial Molina JM, et al. IAC. 2014; Abstract MOAB0105LB.

  2. Sofosbuvir plus Ribavirin for HCV-HIV CoinfectionPHOTON-2 Trial: Study Features Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB.

  3. Sofosbuvir plus Ribavirin for HCV-HIV CoinfectionPHOTON-2 Trial: Overall Demographics Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB.

  4. Sofosbuvir plus Ribavirin for HCV-HIV CoinfectionPHOTON-2 Trial: Treatment Arms 0 12 24 36 Week GT 1,3,4 Naïve Sofosbuvir +RBV(n = 200) SVR12 GT 2 Naïve Sofosbuvir +RBV(n = 19) SVR12 GT 2,3 Experienced Sofosbuvir +RBV(n = 55) SVR12 Drug DosingSofosbuvir: 400 mg once dailyRibavirin (weight-based and divided bid): 1000 mg/day if < 75 kg or 1200 mg/day if ≥ 75 kg Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB.

  5. Sofosbuvir plus Ribavirin for HCV-HIV CoinfectionPHOTON-2 Trial: Results PHOTON-2: SVR 12 with Sofosbuvir + RBV x 12-24 weeks 95/112 17/19 52/57 26/31 5/6 42/49 Treatment Naive Treatment Experienced All received 24-week Rx except 12 week Rx with GT-2 Treatment Naive Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB.

  6. Sofosbuvir plus Ribavirin for HCV-HIV CoinfectionPHOTON-2 Trial: Results PHOTON-2: SVR 12 with Sofosbuvir + RBV, by Genotype 95/112 22/25 94/106 26/31 Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB.

  7. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

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