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Inhibition of Murein Biosynthesis Tutorial

Inhibition of Murein Biosynthesis Tutorial. by. Willie Claiborne Brown, Ph.D. Professor Emeritus University of California, San Diego January, 2001. WCB. Formation of Amino Sugars. NAG. UDP. NAM. UDP. Fructose-6-P. Glutamine (NH 2 ). Acetyl CoA. (NAG). N-Acetylglucosamine. UTP. P.

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Inhibition of Murein Biosynthesis Tutorial

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  1. Inhibition of Murein Biosynthesis Tutorial by Willie Claiborne Brown, Ph.D. Professor Emeritus University of California, San Diego January, 2001 WCB

  2. Formation of Amino Sugars NAG UDP NAM UDP Fructose-6-P Glutamine(NH2) Acetyl CoA (NAG) N-Acetylglucosamine UTP P Phosphoenol Pyruvate(Lactyl) Reduction Steps Other Cell Reactions Murein Biosynthesis

  3. Sequence of Events in Murein Biosynthesis NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG P UDP NAM P NAM P-P Bactoprenol Bactoprenol Bactoprenol Section of Growing Murein NAM NAM Bactoprenol P NAM NAM P-P Bactoprenol P-P NAM UDP NAM 6 5 ATP Cytoplasm [Alanine Branch] 7 ATP ATP 2-4 ATP ATP 1 UDP P UMP 9 8 13 Membrane 10 11 12 14 Exterior [Crosslinking Step]

  4. Inhibition of NAM Formation NAG UDP Fructose-6-P Glutamine(NH2) Acetyl CoA N-Acetylglucosamine (NAG) UTP P Phosphoenol Pyruvate(Lactyl) Reduction Steps Other Cell Reactions Fosfomycin Murein Biosynthesis

  5. WCB Effect of D-Cycloserine on Murein Biosynthesis NAG NAG NAG NAG NAG NAG Section of Growing Murein NAM NAM NAM UDP NAM 5 Cytoplasm [Alanine Branch] 7 ATP 2-4 ATP ATP 1 9 8 13 Membrane 10 11 12 14 Exterior [Crosslinking Step]

  6. Effect of Bacitracin on Murein Biosynthesis NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG P UDP NAM P NAM P-P Bactoprenol Bactoprenol Bactoprenol Section of Growing Murein NAM NAM Bactoprenol P NAM NAM P-P Bactoprenol P-P NAM UDP NAM 6 5 ATP Cytoplasm [Alanine Branch] 7 ATP ATP 2-4 ATP ATP 1 UDP UMP 9 8 13 Membrane 10 11 12 14 Exterior WCB [Crosslinking Step]

  7. Effect of Beta Lactam Antibiotics onMurein Biosynthesis NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG P UDP NAM P NAM P-P Bactoprenol Bactoprenol Bactoprenol Section of Growing Murein NAM NAM Bactoprenol P NAM NAM P-P Bactoprenol P-P NAM UDP NAM 6 5 ATP Cytoplasm [Alanine Branch] 7 ATP ATP 2-4 ATP ATP 1 UDP P UMP 9 8 13 Membrane 10 11 12 14 WCB Exterior [Crosslinking Step]

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