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BioLume

BioLume. Presentation January 10, 2007. BioLume Mission. …..to develop and commercialize a broad library of proprietary bioluminescent proteins with multiple first-in-class applications in diagnostic imaging, food, beverage, and cosmetics…. BioLume Imaging Patents.

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BioLume

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  1. BioLume Presentation January 10, 2007 BioLume

  2. BioLumeMission …..to develop and commercialize a broad library of proprietary bioluminescent proteins with multiple first-in-class applications in diagnostic imaging, food, beverage, and cosmetics….. BioLume

  3. BioLume Imaging Patents • Detection and visualization of neoplastic tissues and other tissues • U.S. 6,416,960 issued July 9, 2002 • U.S. 6,596,257 issued July 22, 2003 • U.S. 09/746485 filed December 22, 2000 • Broad claims e.g., “A diagnostic system containing a bioluminescence generating system” • Backed up by broad composition of matter patents BioLume

  4. Bioluminescence is light produced by a chemical reaction within a living organism What is Bioluminescence? BioLume

  5. Bioluminescent Proteins Visible light BioLume

  6. BioLume’s bioluminescent proteins were cloned from various deep-sea marine organisms Bioluminescent Proteins BioLume

  7. Sardines, Herring, Haddock, Tuna, Salmon, and Mackerel all have diets rich in bioluminescent organisms and contain luciferases and their substrate coelenterazine Bioluminescent Proteins BioLume

  8. Food squid observed during fishery collection Bioluminescent Proteins BioLume

  9. These proteins have already been tested for skin, eye, and oral toxicity (both acute and sub-acute) These proteins were negative for mutagenicity in the Ames test. Many pharmaceutical and university research laboratories have maintained animals expressing Luciferase, with no reports of toxicity or failure of animals or cells to thrive due to their presence. Coelenterazine is a natural antioxidant Bioluminescent Protein Safety BioLume

  10. Molecular Imaging Molecular imaging represents a paradigm shift in the focus of medical imaging from the visualization of anatomy and physiology to the study of metabolic and physiological processes e.g., cancers, often in real time BioLume

  11. Recent advances in biotechnology have enabled in vivo molecular imaging of luciferase reporter proteins in living animals by using a cooled charge-coupled device (CCD) camera. Molecular Imaging BioLume

  12. Bioluminescent Imaging BioLume

  13. Molecular Imaging Because bioluminescence imaging has minimal background activity, this technology is very sensitive for detecting light emitted from luciferases BioLume

  14. Bioluminescent Imaging BioLume

  15. Bioluminescence Molecular Imaging with renilla luciferase BioLume

  16. Bioluminescent Imaging BioLume

  17. Bioluminescent Imaging BioLume

  18. Bioluminescent Imaging BioLume

  19. Bioluminescent Imaging BioLume

  20. >1 million new cases of skin cancer will be diagnosed in the US this year (>10k will die) • 1 in 5 Americans will develop skin cancer during their lifetime (BCC, SCC, or melanoma) • 1 in 65 Americans were likely to develop melanoma during their lifetime • Melanoma incidence has increased 690% since 1950 • Melanoma is the second most common cancer in women aged 20 to 29 • Source: American Academy of Dermatology Skin Cancer Facts BioLume

  21. Screening for skin cancer is a visual exam by patient or dermatologist • Suspicious lesions get a biopsy • Highly specific antibodies for melanoma are known and generically available • There are no skin cancer screening kits on the market today Skin Cancer Detection BioLume

  22. Immunology of Melanoma • There are unique surface antigens which characterize melanoma cells • These unique antigens can be used to target highly specific antibodies, for therapy or detection BioLume

  23. Immunology of Melanoma • One type of surface antigen is a ganglioside (GM3) • Antibodies have been made which are directed against these gangliosides as well as other melanoma surface antigens BioLume

  24. Selective melanoma antibody kill melanoma cells BioLume

  25. Bioluminescent Melanoma Detection Luciferases can be expressed with antibodies to melanoma surface antigen(s) Or Luciferases can be chemically conjugated to the melanoma antibodies BioLume

  26. Summary • Product development opportunity combining known antibodies and developed bioluminescent proteins (no research required) • Patented bioluminescent proteins • Focused on an unmet medical need • Large market opportunity BioLume

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