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Gastroscope

Gastroscope. Advisor: Dr. Ata Akin Design Team: Casey Gavinski Kenneth Hoyt Ashish Patel Kalpesh Trivedi. Problem Background. Diabetes Mellitus Gastroparesis Techniques for Diagnosis Invasive Non-invasive. Invasive. Methods of Diagnosis. Nuclear Medicine Test

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Gastroscope

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  1. Gastroscope Advisor: Dr. Ata Akin Design Team: Casey Gavinski Kenneth Hoyt Ashish Patel Kalpesh Trivedi

  2. Problem Background • Diabetes Mellitus • Gastroparesis • Techniques for Diagnosis • Invasive • Non-invasive

  3. Invasive Methods of Diagnosis • Nuclear Medicine Test • Patient consumes small amount of radioactive material • Scanner monitors amount of radioactivity in stomach • Upper Gastrointestinal (GI) Endoscopy Test • Camera inserted into digestive tract • Visually examines stomach • Intraluminal Manometry • Baloon inserted into stomach • Measures pressure generated by stomach contractions • Electrogastrography (EGG)

  4. Electrogastrography • Measurement of Gastric Myoelectrical Potential Signals • Electrodes placed on abdominal surface • Testing performed during states of Fasting and Postprandial • Correlation between EGG signals and gastric motility Non-Invasive !!

  5. EGG Signal • Gastric Myoelectrical Signals (500μV)

  6. EGG Signal • Primary Frequency Component 3 cpm (0.05 Hz)

  7. Existing EGG Systems • Signal Measurement Bandwidth • 1-18 cpm (0.02-0.3 Hz) • Primary Frequency • Stand Alone • Mobility Limited • Portable • No Graphical Display • Not Stand Alone

  8. Gastroscope • Portable • Stand Alone System • Graphical Display • Increased Bandwidth

  9. EGG Signal • Secondary Frequency Component 50 – 80 cpm (0.8 – 1.3 Hz)

  10. Why the 50 to 80 cpm ? • 3cpm range requires monitoring throughout fasting and postprandial states. (Differential Comparisons) • 50 to 80 cpm range provides consistent results with a short time reading. • 50 to 80 cpm range closely correlated to Intraluminal Manometry Test in dogs. (Diagnostic Charts Available) • Create look-up charts for faster more accurate diagnosis.

  11. Gastroscope System Architecture

  12. Analog Signal Processing • DC Amplifier • Instrumentation Amplifier • Gain > 10,000 • Low Noise • Filter • Low Pass • Flat Response • Sharp Roll-off

  13. Amplifier Schematic

  14. Printed Circuit Board (PCB)

  15. Amplifier Response • Amplifier and filter response to an input of 100 μv at 1 Hz

  16. Amplifier Response (Cont’d) • Amplifier and filter response to an input of 100 μv at 15 Hz

  17. Amplifier Response (Cont’d) • Amplifier and filter response to an input of 1 mv at 1 Hz

  18. Amplifier Response (Cont’d) • Amplifier and filter response to an input of 1 mv at 15 Hz

  19. DSP Flow Chart

  20. Matlab Simulation

  21. Matlab Simulation (Cont’d)

  22. Alternative System Design • Laptop Based Design • Near Real Time Data Analysis • LabVIEW Software • Data Storage in Spreadsheet Format • GUI Interface • Portable • Research Applications • IRB Approved

  23. Future Work • Integrated System • DSP Based Architecture • Properly Configured ADC • Touchscreen Display (LCD)

  24. Senior Design Expenditures

  25. 4 Year Financial Estimation Note: Production at $600 per unit is assumed as follows Year 1 – 20 units Year 2 – 30 units Year 3 – 40 units Year 4 – 50 units

  26. Summary of System Design Laptop Freq = Mag = Power = START STOP SUMMARY RESET National Instruments DAQ AI 16E Amplifier Fiter EGG SYSTEM

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