10 th International ISSX Meeting

1. 10th International ISSX Meeting September 30 – October 3, 2013 Westin Harbour Castle Hotel Toronto, Canada

2. Meeting Venue – Westin Harbour Castle Hotel

3. Proposed Meeting Organizing Committee (MOC) Denis Grant (Chair) Univ of Toronto ON StelvioBandiera UBC, Vancouver BC Jack Bend UWO, London ON Chantal Guillemette Laval Univ, Quebec PQ MalleJurima-Romet Celerion, Montreal PQ Roger Keefe Imperial Oil, Calgary AB David K. Lee NoAb, Mississauga, ON Tom Massey Queen’s Univ, Kingston ON Eddie Morgan Emory Univ, Atlanta GA Sandy Pang Univ of Toronto, Toronto ON Allan Rettie Univ of Washington, Seattle WA David Riddick Univ of Toronto, Toronto ON Nathalie Rioux BoehringerIngelheim, Laval PQ Rachel Tyndale Univ of Toronto, Toronto ON Jack Uetrecht Univ of Toronto. Toronto ON Peter Wells Univ of Toronto, Toronto ON

4. Proposed Scientific Advisory Board (SAB) Ann Daly – Newcastle University, UK Patrick Dansette - Université Paris, France Xinxin Ding – Wadsworth, Albany NY, USA UweFuhr – University Hospital of Cologne, Germany Ron Hines – Medical College of Wisconsin, Milwaukee WI, USA Paul Hollenberg – University of Michigan, Ann Arbor MI, USA Magnus Ingelman-Sundberg – KarolinskaInstutute, Stockholm, Sweden Tetsuya Kamataki – Inst for Genome Function, Fujisawa, Japan Richard Kim – Univ of Western Ontario, London, ON, Canada Steve Leeder – Children's Mercy Hospital, Kansas City MO, USA Peter Mackenzie – Flinders University, Adelaide, Australia Larry Marnett – Vanderbilt Univ, Nashville TN, USA Urs Meyer – Biozentrum, Univ of Basel, Basel, Switzerland Franz Oesch – Univ of Mainz, Mainz, Germany B. Kevin Park - University of Liverpool, Liverpool, UK OlaviPelkonen - University of Oulu, Oulu, Finland Lance Pohl - NIH/NHLBI, Bethesda, Maryland, USA Rory Remmel - University of Minnesota, Minneapolis, Minnesota, USA Glenn Sipes - University of Arizona, Tucson, Arizona, USA Bill Smith (President-Elect) - Pfizer Inc La Jolla Labs, San Diego, California, USA Steve Tannenbaum - MIT, Cambridge, Massachusetts, USA Ken Thummel - University of Washington, Washington, USA Jacques Turgeon - Universite de Montreal, Montreal PQ, Canada Mike Waterman - Vanderbilt University, Nashville, Tennessee, USA David Waxman - Boston University, Boston, Massachusetts, USA Yasushi Yamazoe - Tohoku University, Sendai, Japan UliZanger - Dr. Margarete Fischer-Bosch Institute, Stuttgart, Germany

5. Meeting Schedule – Overview • 4-6 Short Courses • 3 Keynote Lectures • 2 Plenary Sessions • ISSX Awards and Award Lecture • 8-12 Symposia • 4-6 Industry-Sponsored Luncheon Seminars • 3 Days of Poster Viewing • 1 Poster Awards Session • 3 Days of Commercial Exhibits • ½ Day Free Time • Welcome Reception • ISSX Banquet

6. Meeting Schedule - Timetable

7. Keynote Lectures, Plenary Sessions, Symposia and Short Courses Preliminary topics: • Role of inflammation in chemical carcinogenesis • Development and uses of stem cell derived hepatocyte-like cells and cultured transformed cells • Utility and challenges of genome-wide association studies in pharmacogenetics research • Extrapolation from in vitro and cell-based systems to predict in vivo human drug metabolism • Extrapolation of animal drug disposition studies to humans • Utility of genetically modified animals in human drug disposition studies • Toxicogenomic profiling: current status and future utility in drug development • Drug-metabolizing enzymes as therapeutic targets • Receptor cross-talk in the regulation of drug metabolizing enzyme expression • Metabolomic profiling as a tool for identifying novel drug target interactions • Role of oxidative stress in cell physiology and pathology • Pharmacogenomics and translational medicine: promise and challenge • Effect of natural products on drug disposition • Methods for prediction of drug-drug interactions • Systems biology and xenobiotic-host interactions: concepts and technologies • Impact of advanced genome sequencing technologies on personalized medicine • Neuronal damage and neuroprotection against chemical insult • DNA damage and repair mechanisms in cancer risk • Cell type specific cytotoxic mechanisms • New approaches to the development of biomarkers for drug-induced toxicity

8. Projected Attendance Members: 500 Non-members: 200 Students: 300 TOTAL 1000

9. Timeline • Oct 2011– May 2012 (24-16 mo) • MOC/SAB memberships approved and finalized (1 mo) • MOC/SAB meetings/teleconferences/email circulars – scientific program details finalized (7 mo) • May 2012 (16 mo) • Finalized program, speakers and titles sent to SAC • SAC approval of program • June – Oct 2012 (16-12 mo) • Speaker invitations • Identification/approval of satellite meetings

10. Toronto – The City

11. Toronto – Exploring the City Shopping • Bloor Street • Yorkville • St. Lawrence Market • Eaton Centre • Distillery District Arts & Culture • Art Gallery of Ontario • Royal Ontario Museum • Toronto Symphony • Live Theatre • Opera • Sports: MLB Playoffs?! Neighbourhoods • Chinatown • Kensington Market • The Beaches • Little Italy • Queen Street West • Danforth/Greektown • Leaside • Roncesvalles Village • Bloor West Village Walking/Cycling • Harbourfront • Discovery Walk tours • ‘City of Ravines’

12. 10th International ISSX Meeting September 30 – October 3, 2013 Westin Harbour Castle Hotel Toronto, Canada