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بنام خداي زيبائيها

بنام خداي زيبائيها. Major Histocompatibility complex OR. MHC. MHC. The principal function of T cells are : Defense against intracellular microbes Activation of other cells(B cells ,Macrophages ) peptide recognition by T and B cells is different.

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بنام خداي زيبائيها

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  1. بنام خداي زيبائيها

  2. Major Histocompatibility complexOR MHC

  3. MHC • The principal function of T cells are : Defense against intracellular microbes Activation of other cells(B cells ,Macrophages ) • peptide recognition by T and B cells is different. B cells recognize soluble as well as cell associated Ags In contrast ,T cells recognize peptide which is displaying only by APC in associated with MHC proteins.

  4. MHC • MHC genes are the most polymorphic genes • MHC genes are codominantly expressed in each individual • There are two main type of MHC:class I & II • The physiologic function of MHC molecules is presentation of peptides to T cells ,control of immune responsiveness to all proteins and graft rejection • MHC-I present cytosolic peptides to T cytotoxic cells and MHC-II present endocytosed peptides to Thcells

  5. MHC genes

  6. MHC –I structure

  7. MHC-II structure

  8. T cell receptor and MHC interaction

  9. Polymorphism of class II • HLA-DPA 12 • HLA-DPB 88 • HLA-DQA 17 • HLA-DQB 42 • HLA-DR >400

  10. Polymorphism of class I • HLA-A >280 • HLA-B >500 • HLA-C >130

  11. MHC genes and graft rejection

  12. HLA expression

  13. Peptide presentation by MHC-II

  14. Peptide presentation by MHC-I

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