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Behavioral Interventions for HIV/AIDS

Behavioral Interventions for HIV/AIDS. Guest Lecture for Dr. Detels ’ EPI 227 Dallas Swendeman , Ph.D., M.P.H. Co-Director , Global Center for Children and Families (GCCF) Executive Director, Center for HIV Identification, Prevention & Treatment Services (CHIPTS)

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Behavioral Interventions for HIV/AIDS

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  1. Behavioral Interventions for HIV/AIDS Guest Lecture for Dr. Detels’ EPI 227 Dallas Swendeman, Ph.D., M.P.H. Co-Director, Global Center for Children and Families (GCCF) Executive Director, Center for HIV Identification, Prevention & Treatment Services (CHIPTS) Assistant Professor, Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine at UCLA Affiliated Faculty, Department of Epidemiology, UCLA Fielding School of Public Health dswendeman@mednet.ucla.edu http://chipts.ucla.edu/; http://www.uclacommons.com/ April 17, 2013

  2. Behavioral vs. Biomedical • Biomedical interventions • Vaccines, pharmaceutical treatments, & medical devices to prevent & treat disease • Behavioral interventions • Programs that help people change their behaviors to prevent & manage disease • Almost all biomedical interventions require behavior changes – by patients, providers, organizations, etc.

  3. Behavioral vs. Structural • Behavioral Interventions • directly target people to change their behaviors • adoption & utilization of tools or services • adherence to treatments & lifestyle recommendations • Structural Interventions • change in access, availability, or acceptability • Policies, prices, payers, laws • Physical & social environments (culture), organizations, communities

  4. Behavioral vs. Structural • Structural = change in access, avail, accept • Ex. Condom avail, Testing/Tx avail, N&S Exchange/Sale, Policies – States, Orgs, Venues • Behavioral = directly target people to change • Ex. Condom use, Reduce # Partners, Clean Equip., Service Util.

  5. Behaviorally Targeted Structural Interventions • E.g., condom or clean syringe use, treatment util. & adherence • 100% Condom use program – Top Down • Community-led structural intervention (CLSI) • Mobilization of people and resources

  6. Evidence-Based Interventions (EBI) • Systematic programs to support behavior change • Typically a manual guides training & implementation • more structured than an “Evidence-based Practice” • Adopted medical “product development” model • vaccines, pharmaceuticals, devices • Rigorous evaluation of risks and benefits • At least one RCT, but gold standard is 2 RCTs • Some say must be “replicated” by other teams • Some say large-scale “effectiveness” trial needed

  7. A new “Adherence” Paradigm? • “Combination Prevention” of biomedical & behavioral interventions is wave of future • maybe structural • Examples • ART “Treatment as Prevention”, • reduce community viral load & infectio • PrEP & PEP • Reduce susceptibility to HIV exposures • Dependent on uptake & adherence behaviors

  8. What are the Ingredients of Behavioral Interventions? • Not just information • Information is necessary but insufficient for behavioral change • Behavioral intervention design is a “black box” • Not well specified design principles • What are the “Core Elements”?

  9. Behaviors vs. Knowledge, Attitudes, Beliefs (KAB) • Knowledge may be necessary but is often not sufficient for behavior changes • Rational Actor Assumptions  • Health Education vs. Beh. Change (Psychology) • Motivation, Information, Skills, Address Barriers, Support to Sustain change

  10. Behavior Change Theories •  Health Belief Model (Becker) • Knowledge & beliefs • Social Learning theory (Bandura) • Social norms & rewards • Stages of Change (Prochaska & DiClimente) • Pre-contemplation, contemplation, ready, action, relapse, maintenance • Diffusion of Innovations (Rogers) • Community-level • Innovators, early-, middle-, late- adopters

  11. CONSORT Intervention Reporting Domains – Pt. 1 • Content/Elements • Content & How Delivered (oral, written, video, computer, text-message) • Providers • Physicians/Experts/Social Workers vs. Peer/Lay/CHW • Format • Self-help, individual, group, telephone • Setting • Clinic, CBO/NGO, school, classroom, workplace, homes, venues (brothels, bars, clubs) 

  12. CONSORT Intervention Domains Pt. 2 • Recipients • Target populations • Intensity • # of contacts & total contact time • Duration • Period of time & spacing of contacts • Fidelity • Delivered as Intended & Monitored/Measured (M&E) * Need a science of intervention design & delivery

  13. Recipient “Target Population” Risks: • Diagnosed or Infected • High-Risk • Behavioral, genetic, & epidemiological risk factors • At-Risk • Potential for high-risk or infection if there is shift in behavior, environment, or epidemiology • Low-risk * Address stigma & “victim blaming”

  14. Intensity & Duration: • Brief vs. Comprehensive • Sustaining Impact  Generalizing Impact • Duration of behavioral changes • Breadth of behavioral changes

  15. Delivery Formats: • Mass Media (inform vs. behavior change) • Community-level & Networks • Small Group • One-on-One • New Delivery Formats: • Mobile Phones & Internet

  16. Providers: • Professionals (Physicians, Therapists) • vs. • CHWs – Task Shifting • Self-directed? • Stigma

  17. Settings: • Clinical vs. Community (CBO / NGO) • Disease-Specific vs. Wellness & General Health • Age & Gender Segregated vs. Family Focused

  18. Content/Elements: • Almost completely unspecified • new work in this area • Manuals scripted & sequenced • Theory? • Explains hypothesized change process & targets • Rarely specifies the content or techniques • More in common than different (use multiple) • Common Elements • Principles, Processes, Techniques, Practices, • Common Factors • Standardized Functions

  19. Core Elements defined by researcher-developers are not consistent in scope Theoretical Concepts Key Skills Social Support Specific Activities Population characteristics & challenges Delivery formats Recruitment & Outreach Strategies Key Outcomes

  20. The common factors of EBI are: • Frame issue to motivate change • Apply health information to daily life • Build feel, think, do skills • Address environmental barriers • Build sustainable social support

  21. “Framing to Motivate Change” for adolescent HIV prevention Protecting oneself is a source of ethnic or gender pride Protecting virginity demonstrates hope for marriage Protecting partners demonstrates caring and loving relationship

  22. Common Principles of EBI: • Believe in your worth & right to future • Distinguish fact from myth • Evaluate options & consequences • Commit to change • Plan ahead & be prepared • Practice self-control • Know pleasurable alternatives • Negotiate verbally, not non-verbally • Choose to limit your own freedom • Act to help others protect themselves

  23. Plan Ahead and Be Prepared

  24. Common Processes of EBI: Highly Structured Goals, Agendas, Teacher Role Strategies for Group Management Support, Cohesiveness, Self-disclosure, Active Engagement, Cultural Sensitivity Behavioral Management, Fun Feel, Think, Do Skills Cognitive, Affective, & Behavioral Developmental Issues Social identity, Sense of self, Set rules, Promote morality, Focus on future

  25. Fidelity: • Fidelity to what? • Scripted manuals • Essential practices (i.e., Core Elements) • Common factors, processes, principles, practices • Adaptation & Standards of Evidence • Multi-phase trial borrowed from biomedical • If adapted, is it still an EBI? New trial needed? • M&E vs. CQI Feedback Systems

  26. Provider-level Intervention •  Behavior Change like any other • Adopt new practices • Implement with fidelity • Adaptation?

  27. mHealth CHW System (from www.Mobenzi.com, also see www.dimagi.com )

  28. Technology – Mobile Phones • 5 standardized functions for behavioral intv. • Inform – about disease risks, protection, services • Train - new health behaviors and routines • Monitor – behaviors and risks • Shape – behaviors over time with feedback • Support – from peers/family to sustain behaviors • Also for care coordination, CHW support, M&E

  29. SMS “Text-Messaging” & IVR • Text-messaging (SMS) • Interactive Voice Response (IVR) • Multi-media Messaging (MMS) • universally available on all phones (except MMS) • only time-stamped data and time-based prompts • no GPS/location prompts or unobtrusive data • need SMS/IVR back-end system & programming for anything but small-scale SMS applications

  30. Smartphone Apps • maximum options • time, location/GPS, unobtrusive/background, etc. • more technically involved programming • especially for unobtrusive data, battery life, etc. • App incompatibility across phones • even with same OS (Android) not all devices will work • most likely have to provide phones to participants • Researcher/Clinician authorable web-interfaces • under development, e.g., Ohmage.org

  31. Fidelity Monitoring & Support for Intervention Deliverers (& Dose/Exp.)

  32. If we build it, will they come? • Hard to reach populations (stigma) • Engagement Strategies • Costs & Cost-effectiveness • Payers & Sustainability

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