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IRF-7 overexpression in DC Vaccine enhances the generation of HIV-specific central memory CD8+ T cells. IRF-7 induces the generation of multiple pattern of differentiation of HIV-specific CD8+ T cells. Gated on CD8 + CFSE low IFN- g + CD107a +. 30. Tetramer -. Tetramer +. 5%. 20.

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  1. IRF-7 overexpression in DC Vaccine enhances the generation of HIV-specific central memory CD8+ T cells

  2. IRF-7 induces the generation of multiple pattern of differentiation of HIV-specific CD8+ T cells Gated on CD8+ CFSE low IFN-g+ CD107a+ 30 Tetramer - Tetramer + 5% 20 TM CD8+ CFSE low 8% 10 EM GAG Effector 0 87% GAG GAG + IRF-7 GAG + IRF-7 + IFNa Ab CD8+ CFSE low 3% 12% 1% GAG + IRF-7 84%

  3. Conclusions • Our results show that IRF-7 has a direct impact on HIV-specific CD8 T cells and does not induce proliferation of CD4 compartment. • The use of IRF-7 increases the frequency of memory CD8 T cells having strong CTL functions and enhance the generation of central memory phenotype that can mediate long-term protection. • Neutralizing antibody to anti-IFN reverses the IRF-7 enhanced central memory CD8+ generation. • IRF-7 increases the breadth of HIV-specific T cell repertoire, suggesting its role by inducing efficient priming of naïve T cells.

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