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Biosíntesis

“ Ingenol mebutate [ Picato (LEO Pharma ), 2 ] was recently Food and Drug Administration–approved as a first-in-class treatment for actinic keratosis , a precancerous skin condition, and has completed phase II clinical trials for the topical treatment of basal cell carcinomas.”

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Biosíntesis

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  1. “Ingenolmebutate [Picato(LEO Pharma), 2] was recently Food and Drug Administration–approved as a first-in-class treatment foractinickeratosis, a precancerousskin condition, and has completed phase II clinical trials for the topical treatment of basal cell carcinomas.” “Direct isolation [of 2] yields only 1.1 mg of 2 per kg of Euphorbiapeplus, thus requiring an immense amount of plant material to achieve large scale production. Thesemisynthesisrequiresisolation of ingenol (1), which, although available in a more abundant yield of 275 mg of 1 per kg of dried seeds of Euphorbialathryis, still presents a dearth of material.”

  2. Biosíntesis

  3. Biosíntesis Análisisretrosintético

  4. LiNap Aldehído 10: Synlett 1997, 1297

  5. Martin’ssulfurane CDI

  6. Chlorination of carene

  7. Pauson-Khandreaction

  8. Pinacolrearrangement

  9. Martin’ssulfurane Allylic Oxidation with Selenium Dioxide

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