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Revalidatie van spieratrofie & spierzwakte

Revalidatie van spieratrofie & spierzwakte . Ivan Bautmans Frailty in Ageing research group www.vub.ac.be/FRIA. Sarcopenia Rosenberg J Nutr 1997. Age-related loss of muscle mass. 25 yrs. 75 yrs. Roubenoff R. J Gerontol 2003. Muscle weakness; Physical fatigue; Loss of flexibility.

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Revalidatie van spieratrofie & spierzwakte

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  1. Revalidatie van spieratrofie & spierzwakte Ivan Bautmans Frailty in Ageing research group www.vub.ac.be/FRIA

  2. Sarcopenia RosenbergJ Nutr 1997 Age-related loss of muscle mass 25 yrs 75 yrs Roubenoff R. J Gerontol 2003 Muscle weakness; Physical fatigue; Loss of flexibility

  3. Neuroendocrine dysregulation Bauer & SieberExp Gerontol 2008; 43: 674-678

  4. Acute inflammation • Rapid worsening of sarcopenia • Hospitalized geriatric patients with acute infections / after elective surgery • Worse muscle performance ~ Inflammation • Reduced recovery of muscle endurance Bautmans ea.AgeingClin&ExpRes 2005; Mets ea. AmJGeriatrPharmacother 2004; Bautmans ea. JGerontol 2005; Bautmans ea. BMC Geriatrics 2007; Bautmans ea. JAmGeriatrSoc 2008; Bautmans ea. JGerontol 2010; Bautmans ea. JNutrHealth&Ageing 2011; Beyer ea. ExpGerontol 2011; Bautmans ea. Gait & Posture 2011; Beyer ea. BMC Musculoskeletal 2011

  5. Inflammatory response following surgery N=66, age 24-91 yrs, elective abdominal surgery Bautmans ea. J Gerontology 2010

  6. ↑ ↑ Exercise Inflammation Saini ea.Ageing Research Reviews 2009;8:251–267

  7. 70-80% Max resistance Adapted from Williams eaCirculation 2007

  8. N=31, Age=60-80 yrs Bautmans ea.Gerontology 2005; 51: 253-65

  9. 15kg 60kg Peterson ea.Ageing Research Reviews 2010;9:226–237

  10. N=56, aged 68±5yrs HIGH = 2x 10–15 rep @ 80% 1RM LOW = 1× 80–100 rep @ 20% 1RM LOW+ = 1× 60 rep @ 20% 1RM + 1× 10–20 rep @ 40% 1RM Van Roie ea. Exp Gerontol 2013; 48: 1351-61

  11. Inefficient Akt/mTOR signaling pathway • Preference for endurance exercise? • Inflammation-reducing effect of exercise.

  12. N=106, age 53–83 yrs, randomly assigned to • 1yr 3x/wk strength training (60-80% 1RM) + impact exercise (jumping) • 1yr 3x/wk stretching • Training: • ↑muscle strength • functional benefit observed in both groups

  13. N=20, 75± 7 yrs • Fatigue & weakness • 12wk training, ±20min 3x/wk • Results: • No pain • ↑knee strength • ↓TUG

  14. N=57, age 70±7 yrs, randomly assigned to • 12 wks 2x/wk resistance (2-4 stets @ 6RM) + aerobic exercise (20min @ 80% HRmax) • 12 wks usual care • Exercise: • ↑lean mass, ↑ muscle strength, ↑ walk speed, ↑QoL, • ↓fatigue, ↓CRP

  15. Beyer eaCurrent Opinion in Clinical Nutrition and Metabolic Care 2012; 15: 12-22

  16. “myokine” pathway Pro-inflammatory Anti-inflammatory Anti-inflammatory = reduction of chronic low-grade inflammatory profile Pedersen & FebbraioPhysiol Rev 2008; 88: 1379–1406

  17. Acute exercise-induced response N=31, Age=60-80 yrs Bautmans ea.Gerontology 2005; 51: 253-65

  18. Chronic effectsN=31, age=60-80 yrs Bautmans ea.Gerontology 2005; 51: 253-65

  19. 8wk training 3x/wk RT & RTTB ↑intra-muscular IL-6 levels!

  20. Strength training in older cancer patients • Literature is rather scarce • Positive effects can be obtained! • Muscle performance • inflammation • Dose-response relationships remain unclear • Potential interfering factors • Inflammation / cachexia • Chemo/radio therapy or ‘survivor’ • Hormonal treatment

  21. Thank you.ibautman@vub.ac.be http://www.vub.ac.be/FRIA/SPRINT.html

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