Metabolic Disorders in Animal Nutrition

1. Metabolic Disorders in Animal Nutrition AnusornCherdthong, PhD 137748 Applied Biochemistry in Nutritional Science Email: anusornc@kku.ac.th • E-learning: http://ags.kku.ac.th/eLearning/137748

2. Introduction Mammary gland structure

3. Milk composition • 85% water • Lactose • Vitamin • Minerals • Protein: casein, whey protein • Fat

4. Milk composition (%)

5. Milk synthesis and substrates McDonald et al. (2011)

6. Milk synthesis • Lactose synthesis • Protein synthesis • FA synthesis

7. Lactose synthesis McDonald et al. (2011)

8. Lactose synthesis McDonald et al. (2011)

9. Protein synthesis • Milk---casein and few of -lactalbumin, -lactoglobulin • Occurred in endoplasmic reticulum and rough endoplasmic reticulum (RER) • Substrates are AA: diet and microbial protein • Protein product was storaged in golgi • Mechanism protein synthesis similar to other organs

10. FA synthesis • Occurred at smooth endoplasmic reticulum (SER) • triacylglyceride is major product • Storage in alveolus • FA received from: • Diet: intake, synthesis from C2, C4 • Mobilization from adipose tissue

11. Milk synthesis control Brisken and O'Malley (2010)

12. 1 2 3 Conclusion Protein synthesis from diet and microbes Lactose synthesis with 7 steps FA synthesis as triacylglycerol by use VFA, diet as substrate

13. Thank you!