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DNA Priming

Central Memory T cells Enhanced proliferative ability Limited effector function Narrow migration pattern. Peripheral Memory / Effector T cells Reduced proliferative ability High effector function Widespread migration pattern. A. Naïve T cells. PD-1 lo CD62L +. PD-1 lo CD62L +.

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DNA Priming

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  1. Central Memory T cells • Enhanced proliferative ability • Limited effector function • Narrow migration pattern • Peripheral Memory / Effector T cells • Reduced proliferative ability • High effector function • Widespread migration pattern A Naïve T cells PD-1lo CD62L+ PD-1lo CD62L+ PD-1hi CD62L- Exhausted T cells Anti- Infection, Tumor DNA Priming Boosting Immune induction / amplification / re-induction, etc. Vector inducing central memory PD-1lo T cells B Highest immunity throughout Vector inducing peripheral memory PD-1hi T cells Immunity Time Priming vector => Low PD-1 Priming vector => High PD-1 Homologous prime-boosting Heterologous prime-boosting

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