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LIVER& GALLBLADDER

LIVER& GALLBLADDER. Dr Iram Tassaduq. Major salivary glands Gallbladder Pancreas Liver. LIVER. LIVER. Largest mass of glandular tissue Largest internal organ 1500 g in weight. ANATOMY OF LIVER. STRUCTURAL ORGANIZATION. Parenchyma Connective tissue stroma

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LIVER& GALLBLADDER

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  1. LIVER&GALLBLADDER Dr Iram Tassaduq

  2. Major salivary glands • Gallbladder • Pancreas • Liver

  3. LIVER

  4. LIVER • Largest mass of glandular tissue • Largest internal organ • 1500 g in weight

  5. ANATOMY OF LIVER

  6. STRUCTURAL ORGANIZATION Parenchyma Connective tissue stroma Sinusoidal capillaries (sinusoids) Perisinusoidal space (space of Disse)

  7. CAPSULE • The liver is enclosed in a capsule of fibromuscular connective tissue known as Gilson's capsule. • Thin capsule

  8. LIVER CAPSULE

  9. LIVER LOBULES • Classic Lobule • Portal Lobule • Liver acinus

  10. CLASSICAL LOBULE

  11. CLASSICAL LOBULE

  12. PORTAL TRIAD • Hepatic artery • Portal vein • Bile duct

  13. Portal lobule • Emphasizes exocrine function • Includes those portions of three classical lobules that secrete bile that drains unto bile duct

  14. LIVER ACINUS

  15. LIVER ACINUS

  16. BLOOD VESSELS OF PARENCHYMA

  17. DIRECTION OF FLOW OF SUBSTANCES

  18. HEPATIC SINUSOIDS

  19. BLOOD SUPPLY

  20. HEPATIC SINUSOIDS

  21. KUPFFER CELLS

  22. SPACE OF DISSE

  23. STELLATE CELLS

  24. STELLATE CELLS

  25. SECRETION OF BILE

  26. FORMATION OF LYMPH IN THE LIVER • Due to the large pores or fenestrations in sinusoidal endothelial cells, fluid and proteins in blood flow freely into the space between the endothelium and hepatocytes (the "space of Disse"), forming lymph. Lymph flows through the space of Disse to collect in small lymphatic capillaries associated with portal triads.

  27. HEPATOCYTE

  28. GALL BLADDER

  29. MUCOSA

  30. SPECIAL FEATURES OF MUCOSA • Microvilli • Junctional complexes • Concentration of mitochondria • Lateral plications

  31. ROKITANSKY-ASCHOFF SINUSES

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