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STN

Midbrain. SNr GABA. SNc DA. The basal ganglia, Parkinson’s Disease and glutamatergic drive to the substantia nigra . Striatum. DS. Cortex. VS. Jones Lab Web site, animated schematic 1. Thalamus. GPe. GPi. 1. STN. 2.

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STN

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  1. Midbrain SNr GABA SNc DA The basal ganglia, Parkinson’s Disease and glutamatergic drive to the substantia nigra Striatum DS Cortex VS Jones Lab Web site, animated schematic 1 Thalamus GPe GPi 1. STN 2. The basal ganglia circuitry in the mammalian brain is important for motivation and action 1. Loss of substantia nigra dopaminergic neurones occurs in Parkinson’s disease (PD) 2. Glutamatergic drive from the subthalamic nucleus becomes over-active in PD

  2. Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ Mg2+ NMDA glutamate receptors Gly Gly Glu Glu Jones Lab Web site, animated schematic 2 POSTSYNAPTIC DEPOLARIZATION Ca2+: -cell survival -cell death

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