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Nucleic Acids

Nucleic Acids. Let’s Review!. What is a macromolecule? What are the four kinds of organic molecules? What are nucleic acids made of?. - A large organic molecule (made of carbon!). - Carbohydrates, lipids, proteins and nucleic acids. - Phosphate group, 5-carbon sugar, nitrogenous base.

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Nucleic Acids

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  1. Nucleic Acids

  2. Let’s Review! • What is a macromolecule? • What are the four kinds of organic molecules? • What are nucleic acids made of? - A large organic molecule (made of carbon!) - Carbohydrates, lipids, proteins and nucleic acids - Phosphate group, 5-carbon sugar, nitrogenous base

  3. Nucleic Acids • Nucleic Acids are the chemical link between generations dating back to the beginning of life on earth.

  4. Nucleic Acids • A nucleic acid is a complex macromolecule that stores information in cells in the form of a code.

  5. Nucleic Acids • Nucleic acids are made of long chains of nucleotides. • Nucleotides are made of three components: 1. sugar 2. phosphate group 3. nitrogen base

  6. Nucleic Acids • Examples of nucleic acids are : 1. DNA 2. RNA

  7. DNA DNA = deoxyribonucleic acid its components are: 1. deoxyribose (sugar) 2. phosphate group 3. nitrogen base

  8. The Components and Structure of DNA There are four kinds of bases in in DNA: • adenine • guanine • cytosine • thymine

  9. DNA • James Watson and Francis Crick proposed that DNA has a specific pairing between nitrogen bases: Adenine (A) – Thymine (T) Guanine (G) – Cytosine (C) A and G are purines (AGgies eat Purina) C and T are pyrimidines

  10. Watson & CrickDiscovered the structure of DNA

  11. DNA • Watson and Crick also said the paired nitrogen bases formed two long strands of nucleotides that compliment each other.

  12. DNA • Nitrogen Bases are connected between sugars and phosphates • They declared, “This structure is a “double helix”.

  13. The Components and Structure of DNA DNA Double Helix

  14. DNA • DNA forms chromosomes, units of genetic information which pass from parent to offspring. DNA is wound into structures called chromosomes during cell division (prophase)

  15. What are chromosomes??? Nucleotides make upDNA DNAwinds into Chromatin Chromatin condenses intoChromosomes Chromosomes contain Genes Genes are sections of DNA DNA is made of nucleotides Chromosomes contain Instructions for making YOU!!!

  16. DNA • If you unraveled all your chromosomes from all of your cells and laid out the DNA end to end, the strands would stretch from the Earth to the Moon about 6,000 times.

  17. RNA • RNA has a different sugar than DNA • RNA = ribonucleic acid • It’s components are : 1. ribose (sugar) 2. phosphate group 3. nitrogen base

  18. RNA • It also has different bases than DNA adenine --- uracil cytosine --- guanine • RNA is also single stranded, not double stranded like DNA.

  19. Review

  20. DNA Replication

  21. DNA Replication I. Why Must DNA Replicate?  • Every time a cell divides, it must first make a copy of it’s chromosomes. • Therefore, each cell can have a complete set of chromosomes.

  22. What are chromosomes??? Nucleotides make upDNA DNAwinds into Chromatin Chromatin condenses intoChromosomes Chromosomes contain Genes Genes are sections of DNA DNA is made of nucleotides Chromosomes contain Instructions for making YOU!!!

  23. DNA Replication • Without replication, species could not survive and individuals could not successfully grow and reproduce.

  24. DNA Replication II. How DNA Replicates • DNA is a molecule composed of TWO strands, each consisting of a sequence of nucleotides. • The order of the nitrogen bases on one strand mandates the sequence of bases on the complementary strand.

  25. DNA Replication If you know the bases on one strand, you can predict which bases will occur on the complementary strand. A ----- G ----- T ----- C ----- C ----- C ----- T ----- During Replication each strand serves as a template to create a new strand. T C A G G G A This is as easy as break dancing!

  26. Steps in Replication III. Steps In Replication 1) Enzymes break down the hydrogen bonds between the two DNA strands, unzipping the molecule

  27. Steps in Replication 2) As the DNA unzips, free nucleotides (from surroundings in the nucleus) bond to the single strands by base pairing (A-T, G-C)

  28. Steps in Replication 3) Another Enzyme bonds the new nucleotides into a chain ** The result of this process is the formation of TWO DNA molecules, each identical to the original molecule. Replication! Rah,Rah, Rah!

  29. DNA Replication New Strand Original strand Nitrogen Bases Growth Growth Replication Fork Replication Fork DNA Polymerase

  30. DNA Replication

  31. Reflect and Review 1. What are the two types of nucleic acids? 2. What are the three components of a nucleotide? 3. What are the similarities between DNA and RNA? What are the differences? 4. Describe the process of DNA replication. 5. Why does a DNA molecule undergo replication?

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