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National Cancer Institute HIV/AIDS Cancer Programs

National Cancer Institute. National Cancer Institute HIV/AIDS Cancer Programs. Mostafa Nokta, MD Ph.D. Chief, AIDS Cancer Clinical Program Office of HIV and AIDS Malignancy National Cancer Institute. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health.

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National Cancer Institute HIV/AIDS Cancer Programs

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  1. National Cancer Institute National Cancer Institute HIV/AIDS Cancer Programs Mostafa Nokta, MD Ph.D. Chief, AIDS Cancer Clinical Program Office of HIV and AIDS Malignancy National Cancer Institute U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health

  2. Cancers in HIV Disease AIDS-DefiningVirus • Kaposi’s Sarcoma HHV-8 • Non-Hodgkin’s Lymphoma EBV, HHV-8 (systemic and CNS) • Invasive Cervical Carcinoma HPV Non-AIDS Defining • Anal Cancer HPV • Hodgkin’s Disease EBV • Leiomyosarcoma (pediatric) EBV • Squamous Conjunctival Carcinoma HPV (?) • Hepatoma HBV, HCV

  3. Change in Incidence of Cancers in HIV in the cART Era in USA • Kaposi’s sarcoma • CNS Lymphoma • Lymphoma (NHL and CNS) • Lymphoma (HD) • Anal Cancer • Lung Cancer • Cervical Cancer • Breast • Hepatoma Patel P et al, Ann Intern Med 2008;148:728-736

  4. Dual Burden of KSHV and HIV Infection in Africa Fuel an Epidemic of Kaposi’s Sarcoma HIV KS Incidence KS

  5. Office of HIV & AIDS Malignancy AIDS Cancer Clinical Program AIDS Malignancy Program • CFAR • WIHS • MACS • IeDEA • AITRP • AIDS Malignancy Consortium (AMC) • ACSR • INCTR • ACTG • SPOREs (Lung, Lymphoma, Head & Neck)

  6. AIDS Malignancy Clinical Trials Consortium

  7. AIDS Malignancy Consortium (AMC) • Evaluate clinical interventions for the treatment and preventionof malignancies in people with HIV • Investigate the biology of these malignancies in the context of clinical trials • Conduct Phase I, II and III clinical trials • Address issues of international importance in HIV associated malignancies • Contribute specimens and clinical data to the ACSR

  8. AMC International Objectives • Assist with capacity building in developing nations for international HIV-related cancers • Develop AMC-sponsored and co-sponsored collaborative studies with emphasis on trials that: - Employ hypothesis-driven, scientifically sound, locally relevant and feasible therapies - Address important pathogenesis-based questions - Utilize the unique scientific expertise of the AMC

  9. Current International Protocols

  10. AMC International Sites • Uganda, Kampala • Kenya, Nairobi • Zimbabwe, Harare • India, Mumbai, Chennai, Tamil Nadu • Brazil, Sao Paulo • Australia, Darling Hurst, NSW Dr. Mostafa Nokta, Noktam@mail.nih.gov Dr. Ron Mitsuyasu, RMitsuya@mednet.ucla.edu

  11. ACSR MissionTo provide high-quality HIV-associated malignancy specimens to qualified investigators at little or no cost

  12. ACSR Specimens • > 500,000 specimens and growing • Twenty different diagnosis codes (CA and controls) • Types of specimens • Frozen tissues • PBMCs • Plasma • Body fluids (e.g., saliva, urine, CSF) • Formalin – fixed tissues • Associated Clinical Data

  13. ACSRRepresentation East Coast West Coast Mid-Region

  14. “Collections” within the ACSR • TMAs (NHL, KS) • AMC studies • WIHS Study • HIV multi-site autopsies • SF Gay men’s KS epidemiology study (Martin et al.) • International specimens • Thailand HIV+ Plasma (vaccine study) • Rwandan women (WIHS) • Ugandan KS and natural history (Martin et. Al.)

  15. ACS “Resource” • Searchable on the Web • http://acsr.ucsf.edu • Facilitate collaborations with investigators and specimen sources • Procurement of requested specimens if not in the ACSR collection Dr. Mike McGrath MMcGrath@php.ucsf.edu

  16. Cancer Centers Comprehensive Cancer Centers Cancer Centers Dr. Hasnaa Shafik shafikh@mail.nih.gov Planning Centers

  17. International Network for Cancer Treatment and Research • The INCTR is a non for profit, non governmental organization dedicated to helping to build capacity for cancer treatment and research in countries with limited resources. • Capacity building, Palliative care and educational programs • Disease interests: NH lymphoma, cervical cancer Dr. Ian Magrath, PI http://www.inctr.org/

  18. NCI/OHAM Cofunded Programs • MACS, Multicenter AIDS Cohort Study • WIHS, The Women's Interagency HIV Study • CFARs, Centers for AIDS Research • IeDEA, International Epidemiologic Databases to Evaluate AIDS • AITRP, AIDS International Trainingand Research Program

  19. CFAR Map Dr. Geraldina Dominguez domingug@mail.nih.gov

  20. Region 5: Australia, India, Pakistan, Asia • Australia • Cambodia • India • Indonesia • Japan • China • Malaysia • Singapore • Thailand Region 2: Latin America & Caribbean • Argentina • Brazil • Chile • Haiti • Honduras • Peru • Mexico Region 8: East Africa • Kenya • Tanzania • Uganda Region 8: Central Africa • Burundi • Cameroon • Central African Republic • Congo, Dem. Rep. of (Zaire) • Congo, Republic of • Rwanda • Region 1: North America Canada • United States • Botswana • Malawi • Mozambique • South Africa • Zambia • Zimbabwe Region 8: Southern Africa Region 8: West Africa • Mali • Nigeria • Senegal • Benin • Cote d'Ivoire • Gambia NCI NICHD

  21. Funding Opportunities for AIDS Malignancies Research on Malignancies in the Context of HIV/AIDS (R01 and R21) http://grants.nih.gov/grants/guide/pa-files/PA-07-454.html and http://grants.nih.gov/grants/guide/pa-files/PA-07-455.html Research on Non-AIDS Defining Cancers & AIDS-associated Malignancies Tentative

  22. Hepatocellular Carcinoma • PA-08-243 R01 (Research Grants) http://grants.nih.gov/grants/guide/pa-files/PA-08-243.html • PA-08-244 R21 (Exploratory/Developmental Grants) http://grants.nih.gov/grants/guide/pa-files/PA-08-244.html • PAR-08-245 P01 (Program Project Grants) http://grants.nih.gov/grants/guide/pa-files/PAR-08-245.html

  23. Capacity Building RFA: Strengthening Capacity for HIV-Associated Malignancies in Africa • PI from a US institution and an African Institution • Will support training in all disciplines from basic to clinical research to lay the foundation for the African/US investigators to seek future independent research grants on AIDS-related cancers

  24. International Conference on Malignancies in AIDS & Other Acquired Immunodeficiencies 12th ICMOI, April 26 & 27, 2010 Bethesda, MD, USA For more Information: Contact: Dr. Rebecca Huppi, liddellr@exchange.nih.gov Ms. Denise Jenkins, Jenkinde@mail.nih.gov

  25. HIV Cancer Resources Office of HIV and AIDS Malignancy (OHAM) WEB Site http://oham.cancer.gov/

  26. Enhance Collaborations

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