140 likes | 632 Views
Seizure Disorders and Epilepsy. Seizure is a paroxysmal, uncontrolled electrical discharge of neurons in the brain that interrupts normal function. Seizures are often symptoms of an underlying illness.
E N D
Seizure Disorders and Epilepsy • Seizure is a paroxysmal, uncontrolled electrical discharge of neurons in the brain that interrupts normal function. Seizures are often symptoms of an underlying illness. • They may accompany a variety of disorders, or they may occur spontaneously without any apparent cause. • Seizures resulting from systemic and metabolic disturbances are not considered epilepsy if the seizures cease when the underlying problem is corrected. • In the adult, metabolic disturbances that cause seizures include acidosis, electrolyte imbalances, hypoglycemia, hypoxia, alcohol and barbiturate withdrawal, dehydration, and water intoxication. • Extracranialdisorders that can cause seizures are heart, lung, liver, or kidney diseases; lupus ; diabetes mellitus; hypertension; and septicemia.
Seizure Disorders and Epilepsy • Epilepsy is a condition in which a person has spontaneous recurring seizures caused by a chronic underlying condition. • In the United States it is estimated that more than 3 million people have active epilepsy, with 200,000 new cases diagnosed each year. • National trends show that incidence of epilepsy is decreasing in children and increasing in the elderly. • The highest incidence of new-onset epilepsy occurs in people over 60 years old. • New cases of epilepsy are more common in African Americans and in socially disadvantaged populations. • Males are slightly more likely to develop epilepsy than females. • Populations at higher risk to develop epilepsy include those with Alzheimer's disease, those who have had a stroke, and persons with a parent who has epilepsy.
Etiology and Pathophysiology • The most common causes of seizure disorder during the first 6 months of life are severe birth injury, congenital defects involving the central nervous system (CNS), infections, and inborn errors of metabolism. • In patients between 2 and 20 years of age, the primary causative factors are birth injury, infection, trauma, and genetic factors. • In individuals between 20 and 30 years of age, seizure disorder usually occurs as the result of structural lesions, such as trauma, brain tumors, or vascular disease. • After 50 years of age, the primary causes of seizure disorders are cerebrovascular lesions (stroke) and metastatic brain tumors. • Although many causes of seizure disorders have been identified, three fourths of all seizure disorder cases cannot be attributed to a specific cause and are considered idiopathic.