Global Health Program Guiding Principles

1. Global Health Program Guiding Principles April 2002

2. Global Health Program Guiding PrinciplesApril 2002 Principles • Concentrate on the largest, most inequitable global health problems facing developing countries • Focus on improving public health through prevention and development and deployment of 21st-century, affordable, and high­impact health tools and technology • Invest in efforts that are likely to be sustained over time • Catalyze new/incremental dollars • Demonstrate high-impact interventions and ensure their widespread deployment • Do not displace governments, industry, and/or other donors • Build global awareness of public health inequities in the developing word • Support leadership training for public health leaders in developing countries Goal Increase global health equity by accelerating the development, deployment, and sustainability of tools and technologies that will save lives and dramatically reduce the disease burden in the developing world

3. R&D for innovative tools and technologies Demonstration programs Catalytic financing mechanisms Leadership and Advocacy* Global Health Program Strategy GoalIncrease global health equity by accelerating the development, deployment and sustainability of tools and technologies that will save lives and dramatically reduce the disease burden in the developing world “Build it” “Prove it” “Ensure access” “Support the future” • Support programs that demonstrate scalability and reliability and ensure systems change by • Testing innovative tools and technologies • Evaluating impact of new models • Eliminating or eradicating diseases as opportunities arise • Invest in key commodity funds to ensure that developing countries have sustainable access to existing and new tools/interventions through • Matching grants • Grants contingent on country/other donors’ commitment • Build support for reducing health inequities by • Supporting training for public health leadership in developing countries • Influencing international standards and policies • Disseminating info on proven concepts • Increasing visibility of effective public health and prevention approaches • *Under development – not currently accepting proposals • Develop innovative tools and technologies that will • Enable prevention, elimination or eradication of diseases • Reduce the cost of currently available interventions and increase affordability in low resource settings

4. R&D for innovative tools and technologies Demonstration programs Catalytic financing mechanisms Leadership and Advocacy* HIV/AIDS and TB Program GoalPrevent the transmission of HIV/AIDS, STDs and TB by developing tools, demonstrating novel interventions and catalyzing funding, leadership and advocacy “Build it” “Prove it” “Ensure access” “Support the future” • Supporting training for public health leadership in developing countries • Influence international standards and policies • Gather evidence and disseminate information on proven concepts • Increase visibility of effective prevention and public health approaches • *Under development – not currently accepting proposals • Develop and test cost-effective vaccines, drugs and diagnostics appropriate for prevention and control in resource-poor settings for HIV/AIDS, STDs, and TB, • Test novel interventions to demonstrate proof-of-concept • Support integrated country programs to reduce HIV and STD transmission in countries with rapidly increasing prevalence and high potential impact on global disease burden, as well as in high-prevalence countries with a generalized epidemic* • Develop mechanisms to catalyze and ensure sustained support from countries and partners for proven tools and service delivery

5. R&D for innovative tools and technologies Demonstration programs Catalytic financing mechanisms Leadership and Advocacy* Infectious Disease and Vaccines Program Goal Save lives and reduce disability due to infectious diseases by developing and deploying cost-effective and sustainable tools in order to break transmission of, eliminate or eradicate diseases “Build it” “Prove it” “Ensure access” “Support the future” • Accelerate development, clinical testing, and approval of vaccines for highest-burden and orphan diseases • Develop and support innovative vaccine formulations and new antigen delivery systems • Develop new drugs and diagnostics, especially those that will assist in breaking transmission or eradication/elimination • Promote regulatory harmonization and accelerated approval for key products • Utilize available methods to eradicate or eliminate targeted diseases (e.g. polio, lymphatic filariasis) • Implement high-impact transmission reduction interventions as appropriate (e.g., trypanosomiasis) • Demonstrate "proof of concept" for new interventions, delivery mechanisms and eradication/elimination strategies • Catalyze innovative approaches for financing, purchasing, and delivering technology to developing countries • Strengthen global and national capacity to finance deployment of new technology (e.g., production, clinical trials) • Supporting training for public health leadership in developing countries • Influence international standards and policies • Gather evidence and disseminate information on proven concepts • Increase visibility of effective prevention and public health approaches • *Under development – not currently accepting proposals

6. R&D for innovative tools and technologies Demonstration programs Catalytic financing mechanisms Leadership and Advocacy* Reproductive and Child Health Program GoalReduce total fertility and maternal and child mortality and morbidity through technology introduction and systems change “Build it” “Prove it” “Ensure access” “Support the future” • Support programs to accelerate the transition to low fertility and low mortality in focus countries. • Support programs to evaluate existing maternal health and adolescent reproductive health programs • Support efforts to fortify staple foods with essential micronutrients and promote micronutrient supplementation of staple foods • Develop innovative reproductive health technologies that will support and accelerate systems change, including new contraceptives for women and men and STD diagnostics • Support organizations that mobilize funds for reproductive heath from other donors • Develop financing mechanisms to ensure access to reproductive health supplies including contraceptives, microbicides, point-of-care STD diagnostics, and antibiotics for STDs • Supporting training for public health leadership in developing countries • Influence international standards and policies • Gather evidence and disseminate information on proven concepts • Increase visibility of effective prevention and public health approaches *Under development – not currently accepting proposals

7. For Grant Seekers • The foundation's grantmaking philosophy flows from our belief that every human life has equal value. In deciding how to invest our resources most responsibly, we look for projects that: • Help reduce inequities in neglected areas • Produce measurable results • Catalyze increased momentum, scale, and sustainability of change • Collaborate with government, philanthropic, private-sector, and not-for-profit partners • Favor preventative approaches • Leverage support from other sources • Advance our current strategies, accelerating the work we are already supporting

8. Global Health Grantmaking Areas • Please read the Global Health Program strategy and review the information below carefully before submitting a request for funding to ensure that your project falls within the foundation’s scope. Grantmaking Areas Funded Primarily Through Letters of Inquiry (LOIs) In general, the foundation accepts LOIs in the following three areas. Please note that there are some exceptions where the foundation only accepts requests for proposals (RFPs). Priority Diseases and Conditions: • Acute diarrheal illness • Acute lower respiratory infections • Child health • HIV/AIDS • Malaria • Malnutrition and undernutrition • Reproductive and maternal health • Tuberculosis • Vaccine-preventable diseases

9. The foundation supports efforts to address diseases that have a lower overall burden than those noted above, but still have a disproportionate impact in the developing world: • Helminthic infections: Lymphatic filariasis, onchocerciasis, schistosomiasis, cysticercosis, Guinea worm, and intestinal nematodes. • Sexually transmitted infections: Gonorrhea, syphilis, and chlamydia. • Kinetoplastid diseases: Human African trypanosomiasis, visceral leishmaniasis, and Chagas disease. • Cervical cancer caused by human papillomavirus. • Other diseases: Meningitis, dengue, Japanese encephalitis, and trachoma.

10. Helminthic Infections  Helminths—a diverse group of multicellular organisms, including worms, which infect humans through various means—are among the world’s most common infections. The foundation supports a range of solutions for these diseases, described below. Ideal interventions would target multiple helminthic infections at the same time, as well as related diseases such as trachoma. Lymphatic FilariasisLymphatic filariasis affects more than 120 million people worldwide, mainly in India and Africa. A third of people who are infected are seriously incapacitated and disfigured by the disease. This condition can be treated with safe, inexpensive drugs, but available regimens do not eliminate the worm and treatment must be repeated at least once annually. Priority Strategies for Grantmaking Eliminating disease by developing sustainable approaches for making better use of available drugs and drug combinations, supplemented by other measures such as vector control.Improving treatment outcomes through research to develop a macrofilaricide drug that can eliminate the worm.

11. Critical Enabling StrategiesTo ensure that life-saving health interventions reach those who need them most, the foundation supports efforts to: • Mobilize new resources for global health, including innovative financing and product procurement mechanisms. • Build awareness of global health issues among decision-makers, the media, and the public. • Strengthen public health leadership. • Improve the collection and use of data and evidence for global health decision-making. • Improve the delivery of, and demand for, key products and interventions. • For disease-specific initiatives, also see Priority Diseases and Conditions, above

12. Grantmaking Priorities for Other Infectious Diseases • The foundation invests in the discovery, development, clinical testing, and introduction of solutions for the following diseases and health conditions. • Helminthic Infections • Sexually Transmitted Infections (STIs) Other Than HIV • Kinetoplastid Diseases • Human Papillomavirus (HPV) • Other Diseases • The foundation also works with grantees and others to secure financing for the introduction and adoption of new health solutions, and to address, well in advance of product approval, the obstacles to product procurement, distribution, and access.

13. How To Apply for a Grant Please note that the foundation does not accept unsolicited full grant proposals. Understand Our Program StrategyBefore applying for a grant, please read about our overall global health strategy. Respond to a Request for ProposalFind out if any requests for proposals have been issued in your field of interest. Submit a Letter of Inquiry (LOI)If your project aligns with our grantmaking priorities and does not fall under one of our current RFPs, please submit an LOI. Click on the link below to learn more about the LOI process.