180 likes | 329 Views
Counting evolutionary changes. the parsimony method requires an algorithm that counts the number of evolutionary changes in a tree. Fitch W.M. 1971. Syst . Zool. 20: 406-416. The Fitch algorithm. the Fitch algorithm counts the number of changes in a tree with nucleotide sequence data
E N D
Counting evolutionary changes the parsimony method requires an algorithm that counts the number of evolutionary changes in a tree. Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Fitch algorithm the Fitch algorithm counts the number of changes in a tree with nucleotide sequence data (A, C, T, G) Walter M. Fitch Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Fitch algorithm for a given site, note the bases observed in the tip species. [C] [A] [C] [A] [G] Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Fitch algorithm the number of changes equals the number of empty intersections. [C] [A] [C] [A] [G] intersection is empty; create union, count+1. intersection is empty; create union, count+1. [AC] [AG] intersection is empty; create union, count+1. [ACG] intersection not empty; note intersection. [AC] Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Fitch algorithm is not required for invariant sites (AAAAAAA) sites with a single variant base (AATAAAA) sites with similar patterns (TCTCA = CACAG) Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Sankoff algorithm in the Sankoff algorithm, not all changes are equally likely. David Sankoff Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Sankoff algorithm the cost of a transition is 1 purine pyrimidine purine pyrimidine purine pyrimidine purine pyrimidine Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Sankoff algorithm the cost of a transversion is 2.5. purine pyrimidine [C] [A] [C] [A] [G] purine pyrimidine purine pyrimidine purine pyrimidine Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Sankoff algorithm [C] [A] [C] [A] [G] AC + AA =2.5 + 0 =2.5 Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Sankoff algorithm [C] [A] [C] [A] [G] Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Sankoff algorithm [C] [A] [C] [A] [G] Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Sankoffalgorithm [C] [A] [C] [A] [G] AC =2.5 AA=0 Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Sankoffalgorithm [C] [A] [C] [A] [G] CC =0 CA=2.5 Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Sankoffalgorithm [C] [A] [C] [A] [G] GC =2.5 GG=0 Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Sankoffalgorithm [C] [A] [C] [A] [G] TC =1 TA=2.5 Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Sankoffalgorithm [C] [A] [C] [A] [G] AA =0 AA =0 Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Sankoffalgorithm [C] [A] [C] [A] [G] TT =0 TC =1 minimal cost of tree Fitch W.M. 1971. Syst. Zool. 20: 406-416.
The Sankoff algorithm the Sankoff algorithm is an example of a dynamic programming algorithm – it solves a large problem by first solving some smaller problems. David Sankoff Fitch W.M. 1971. Syst. Zool. 20: 406-416.