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Population Health for Health Professionals. Module 2. Epidemiology The Basic Science of Public Health. OBJECTIVES. epidemiology and role as foundation for public health common measures of disease frequency strengths and weaknesses of study designs applications of epidemiologic method.
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Module 2 Epidemiology The Basic Science of Public Health
OBJECTIVES • epidemiology and role as foundation for public health • common measures of disease frequency • strengths and weaknesses of study designs • applications of epidemiologic method
Part I Key Terms and Measures
Epidemiology • Study of distribution of determinants and antecedents of health and disease in human populations • Application of results to control of health problems
From Hippocratesto John Graunt • Fifth century BCE, Hippocrates pointed to the need to understand the environment and the risks it posed to understand the experience of disease • 1662, John Graunt analyzed weekly reports of births and deaths in London, quantifying patterns of disease in the population
From William Farrto John Snow • 200 years later, Dr. William Farr was made responsible for medical statistics in the Office of the Registrar General for England and Wales • A mere 20 years later, John Snow completed his study of cholera
Modern Experiences • Evaluation of risk factors for chronic diseases using case controls • Long term population studies using cohorts • Design of clinical trials to evaluate interventions
Expected level Endemic Sporadic Epidemic Pandemic Three Essential Components • Disease distribution • Disease determinants • Disease frequency
Epidemiologic Studies • Descriptive • Analytic
Descriptive Studies • Frequency of occurrence of particular condition • Patterns of occurrence according to person, place and time
Analytic Studies • Observational studies • case-control studies • cohort studies • prospective • retrospective • Experimental studies
Case Control Study Exposure Disease ? ? Key Basis for selection of group for study = present = absent
Prospective Cohort Study Exposure Disease ? ? Key Basis for selection of group for study = present = absent
Retrospective Cohort Study Exposure Disease ? ? Key Basis of selection of group for study = present = absent
Analytic Studies • Observational studies • Experimental studies • Intervention studies • Clinical trials
Basic Presentation of Results All rates and ratios discussed can be calculated from this.
Bias information selection Confounding extraneous factors Effect modification statistical interaction Interpreting Results: Measurement Errors
Strength of the association Consistency Temporality Plausibility Biological gradient Interpreting Results: Cause-Effect Relationship
Measures of Disease Frequency • Prevalence • Incidence
Prevalence= number of existing cases divided by total population Visual examination survey 310 X 100 = 12.5% 2477 Prevalence
Incidence • Incidence = number of new cases in a given period of time divided by the total population at risk • Bacteremia among contraceptive users • 27/483 X 100 = 5.6%
Crude Category specific Age adjusted Rates Commonly Used in Epidemiology
Module Author Fran C. Wheeler, Ph.D School of Public Health University of South Carolina