Memory Human Neurobology 217 Jana Vukovic jvukovic@anhb.uwa.au

1. MemoryHuman Neurobology 217Jana Vukovic jvukovic@anhb.uwa.edu.au

2. Key points: • Famous cases of memory deficit • Brain structures involved – hippocampus • Circuitry of memory – Papez Circuit • synapse strengthening and long-term potentiation (LTP)

3. What is memory? • Memory is defined as the acquisition, storage, and retrieval of information. • All animals learn things from their interaction with the environment • Human brain forms memories more effectively than others • Maximum behavioural flexibility and most efficiently adaptation to environment.

4. Retrograde amnesia Cannot remember events prior to brain damage Anterograde amnesia Cannot later remember events that occur after brain damage Brain damage occurs time Amnesias = memory disorder

5. HM & NA • Which brain structures were removed from HM’s brain? • Hippocampus, hippocampal gyrus, amygdala, uncus were removed on both sides • Which brain structures are damaged in NA? • Thalamusand medial temporal lobe, mammilary bodies missing on both sides • Can HM and NA form new long-term memories (declarative)? • NO. • Can HM and NA learn new skills (procedural)? • YES. • What kind of amnesia do HM and NA have? • Sever anterograde amnesia.

6. NA

7. Korsakoff's syndrome: • Found mostly in alcoholics who get most of their calories from alcohol and become vitamin deficient (thiamine deficiency) • Damages mammilary bodies and other nearby parts of the hypothalamus and thalamus • This damage produces an amnesia similar to the type of NA and HM (sever anterograde amnesia) • Altzheimer’s disease: • Loss of neurons in hippocampal and prefrontal cortex produce first signs of memory loss.

8. Long-term memories are biologically different from short-term memories • Long-term memories are stored throughout the brain, but the hippocampus is necessary for the information to reach long-term storage.

10. Long-term memory Declarative Memory (explicit) Procedural Memory (implicit) Remembering events (episodic m.) Skills and habits Emotional association Knowing facts (semantic m.) Conditioned reflexes Hippocampus Nearby cortical areas, diencephalon cerebellum Striatum Motor areas of cortex cerebellum amygdala

11. Hippocampus • Essential for declarative memory • Cylindrical structure • Longitudinal axis surround thalamus

14. Out put from hippocampus

18. Prefrontal cortex Association cortex Cingulate gyrus Anterior Thalamic nuclei Mammillo thalamic tract Mamillary body fornix Hippocampal formation Hypothalamus Amygdala

19. Strengthening of synapses • Long-term potentiation (LTP) is the long-lasting strengthening of the connection between two neurons • can last from hours to days, months, and years.

20. Long-term potentiation of synapses • Hippocampal slice preparation to study LTP • single stimulation to input path • measure hippocampal response baseline • Give train of stimulation to input path • Again give single stimulation to input path • hippocampus response is larger (potentiated) • Give single stimulation a week later • Hippocampus response still potentiated (long term potentiation)

21. Synapses are strengthened

22. More dendritic spines on dendrites where new synapses are made Dendritic spines from a cerebellar Purkinje cell, drawn by Cajal (Ramón y Cajal, 1899b).

23. Long-term potentiation Only strong stimulus will dislodge Mg2+ from the NMDA receptor

26. Exercise and trophic factor production in the adult brain

27. Describe Papez circuit?

28. Last Slide