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Lecture 19: Translation, regulation of gene expression

Lecture 19: Translation, regulation of gene expression. Lac repressor bound to DNA. Announcements. Final exam date will NOT be changed: Exam will be Friday May 6, 8:00 a.m. Quiz 3 is next Tuesday, April 5 topics – Lecture 15 (structure of DNA) through today problems – Homeworks 8 and 9.

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Lecture 19: Translation, regulation of gene expression

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  1. Lecture 19: Translation, regulation of gene expression Lac repressor bound to DNA

  2. Announcements Final exam date will NOT be changed: Exam will be Friday May 6, 8:00 a.m. Quiz 3 is next Tuesday, April 5 topics – Lecture 15 (structure of DNA) through today problems – Homeworks 8 and 9

  3. Interaction sites on the ribosome

  4. Polyribosomes

  5. Protein folding

  6. Prokaryotic ribosome Steitz laboratory, Yale University

  7. Lactose metabolism also need lacpermease to get lactose into the cell

  8. Coordinate regulation of lac genes

  9. The lacoperon

  10. Lac mutants support the operon model

  11. Partial diploids distinguish cis-acting from trans-acting mutations

  12. The catabolite activating protein (CAP) positively regulates the lacoperon

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