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The functional role of neural activity preceding  memory formation

The functional role of neural activity preceding  memory formation. BUCNI project presentation 19 Feb 2009. Leun Otten & Matthias Gruber. • Part of BBSRC project grant application • Aim: to understand the neural correlates of anticipatory processes in encoding • MEG and fMRI. Event.

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The functional role of neural activity preceding  memory formation

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  1. The functional role of neural activity preceding  memory formation BUCNI project presentation19 Feb 2009 Leun Otten & Matthias Gruber • Part of BBSRC project grant application • Aim: to understand the neural correlates of anticipatory processes in encoding • MEG and fMRI

  2. Event Event Event Event Time Background • Neural activity elicited by an event can index its successful encoding into memory • Recently, shown that encoding is also influenced by activity before an event • Important for several reasons • Largely unknown what brain regions underlie encoding-related pre-stimulus activity • EEG work suggests role for semantic preparation

  3. ROSE Incidental study phase CAT Recognition memory test Delay (~20 min) TABLE In scanner Outside scanner • 120 words in living/non-living and alphabetic/non-alphabetic study tasks • 120 null events • Cue-word and inter-trial intervals optimized to allow maximum separation of activity before and after word onset o x Time o Current study • Aim: to assess which brain regions show activity that precedes memory formation in semantic and non-semantic study tasks • Design: • Study phase:

  4. Questions/contrasts of interest • Basic contrast is between study items that are later remembered vs. forgotten (‘subsequent memory effects’) • Which regions show pre-stimulus subsequent memory effects in the semantic study task? LIFG, MTL, PPC, midbrain? Do these regions overlap with those differentiating semantic vs. non-semantic preparation? • Which regions (if any) show pre-stimulus effects in the non-semantic study task? • Is there overlap between the regions demonstrating pre- and post-stimulus effects? • Does pre-stimulus activity predict an individual’s overall memory performance? fMRI methods Scanning • Rapid event-related fMRI sequence • Whole-head scanning • Two sessions of about 25 min each plus structural • 16 subjects with acceptable memory performance (twenty 1.5-hour slots) • SPM, modeling pre- and post-stimulus activity simultaneously, random effects analyses

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